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. 2024 Apr 1;34(4):bhae172.
doi: 10.1093/cercor/bhae172.

Longitudinal MRI of the developing ferret brain reveals regional variations in timing and rate of growth

Kara E Garcia  1   2 , Xiaojie Wang  3 , Sarah E Santiago  4 , Stuti Bakshi  3 , Anthony P Barnes  4 , Christopher D Kroenke  3   5
Affiliations

Longitudinal MRI of the developing ferret brain reveals regional variations in timing and rate of growth

Kara E Garcia et al. Cereb Cortex. .

Abstract

Normative ferret brain development was characterized using magnetic resonance imaging. Brain growth was longitudinally monitored in 10 ferrets (equal numbers of males and females) from postnatal day 8 (P8) through P38 in 6-d increments. Template T2-weighted images were constructed at each age, and these were manually segmented into 12 to 14 brain regions. A logistic growth model was used to fit data from whole brain volumes and 8 of the individual regions in both males and females. More protracted growth was found in males, which results in larger brains; however, sex differences were not apparent when results were corrected for body weight. Additionally, surface models of the developing cortical plate were registered to one another using the anatomically-constrained Multimodal Surface Matching algorithm. This, in turn, enabled local logistic growth parameters to be mapped across the cortical surface. A close similarity was observed between surface area expansion timing and previous reports of the transverse neurogenic gradient in ferrets. Regional variation in the extent of surface area expansion and the maximum expansion rate was also revealed. This characterization of normative brain growth over the period of cerebral cortex folding may serve as a reference for ferret studies of brain development.

Keywords: cortical plate; logistic growth; longitudinal design; magnetic resonance imaging.

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References

    1. Avants BB, Tustison NJ, Song G, Cook PA, Klein A, Gee JC. A reproducible evaluation of ANTs similarity metric performance in brain image registration. NeuroImage. 2011:54(3):2033–2044. 10.1016/j.neuroimage.2010.09.025. - DOI - PMC - PubMed
    1. Barnette AR, Neil JJ, Kroenke CD, Griffith JL, Epstein AA, Bayly PV, Knutsen AK, Inder TE. Characterization of brain development in the ferret via MRI. Pediatr Res. 2009:66(1):80–84. 10.1203/PDR.0b013e3181a291d9. - DOI - PMC - PubMed
    1. Bayer SA, Altman J. Neocortical development. New York: Raven Press; 1991.
    1. Bayly PV, Okamoto RJ, Xu G, Shi Y, Taber LA. A cortical folding model incorporating stress-dependent growth explains gyral wavelengths and stress patterns in the developing brain. Phys Biol. 2013:10(1):016005. 10.1088/1478-3975/10/1/016005. - DOI - PMC - PubMed
    1. Csernansky JG, Gillespie SK, Dierker DL, Anticevic A, Wang L, Barch DM, Van Essen DC. Symmetric abnormalities in sulcal patterning in schizophrenia. NeuroImage. 2008:43(3):440–446. 10.1016/j.neuroimage.2008.07.034. - DOI - PMC - PubMed

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