Distinct patterns of voxel- and connection-based white matter hyperintensity distribution and associated factors in early-onset and late-onset Alzheimer's disease
- PMID: 38651161
- PMCID: PMC11033836
- DOI: 10.1002/dad2.12585
Distinct patterns of voxel- and connection-based white matter hyperintensity distribution and associated factors in early-onset and late-onset Alzheimer's disease
Abstract
Introduction: The distribution of voxel- and connection-based white matter hyperintensity (WMH) patterns in early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD), as well as factors associated with these patterns, remain unclear.
Method: We analyzed the WMH distribution patterns in EOAD and LOAD at the voxel and connection levels, each compared with their age-matched cognitively unimpaired participants. Linear regression assessed the independent effects of amyloid and vascular risk factors on WMH distribution patterns in both groups.
Results: Patients with EOAD showed increased WMH burden in the posterior region at the voxel level, and in occipital region tracts and visual network at the connection level, compared to controls. LOAD exhibited extensive involvement across various brain areas in both levels. Amyloid accumulation was associated WMH distribution in the early-onset group, whereas the late-onset group demonstrated associations with both amyloid and vascular risk factors.
Discussion: EOAD showed posterior-focused WMH distribution pattern, whereas LOAD was with a wider distribution. Amyloid accumulation was associated with connection-based WMH patterns in both early-onset and late-onset groups, with additional independent effects of vascular risk factors in late-onset group.
Highlights: Both early-onset Alzheimer's disease (EOAD) and late-onset AD (LOAD) showed increased white matter hyperintensity (WMH) volume compared with their age-matched cognitively unimpaired participants.EOAD and LOAD exhibited distinct patterns of WMH distribution, with EOAD showing a posterior-focused pattern and LOAD displaying a wider distribution across both voxel- and connection-based levels.In both EOAD and LOAD, amyloid accumulation was associated with connection-based WMH patterns, with additional independent effects of vascular risk factors observed in LOAD.
Keywords: early‐onset Alzheimer's disease; late‐onset Alzheimer's disease; white matter hyperintensities.
© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Conflict of interest statement
All authors declare no conflicts of interest.
Figures
![FIGURE 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11033836/bin/DAD2-16-e12585-g003.gif)
![FIGURE 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11033836/bin/DAD2-16-e12585-g004.gif)
![FIGURE 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11033836/bin/DAD2-16-e12585-g001.gif)
![FIGURE 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/11033836/bin/DAD2-16-e12585-g002.gif)
Similar articles
-
White matter hyperintensities are higher among early-onset Alzheimer's disease participants than their cognitively normal and early-onset nonAD peers: Longitudinal Early-onset Alzheimer's Disease Study (LEADS).Alzheimers Dement. 2023 Nov;19 Suppl 9(Suppl 9):S89-S97. doi: 10.1002/alz.13402. Epub 2023 Jul 25. Alzheimers Dement. 2023. PMID: 37491599 Review.
-
Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment.Cortex. 2016 Jan;74:217-32. doi: 10.1016/j.cortex.2015.10.014. Epub 2015 Nov 17. Cortex. 2016. PMID: 26694580
-
Distinct Patterns of Interhemispheric Connectivity in Patients With Early- and Late-Onset Alzheimer's Disease.Front Aging Neurosci. 2018 Sep 6;10:261. doi: 10.3389/fnagi.2018.00261. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30237764 Free PMC article.
-
Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort.Alzheimers Res Ther. 2019 Jan 24;11(1):12. doi: 10.1186/s13195-018-0460-1. Alzheimers Res Ther. 2019. PMID: 30678723 Free PMC article.
-
Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.Cell Cycle. 2018;17(19-20):2321-2334. doi: 10.1080/15384101.2018.1515554. Epub 2018 Sep 20. Cell Cycle. 2018. PMID: 30231670 Free PMC article. Review.
References
-
- Schell M, Ossenkoppele R, Strandberg O, et al. Distinct 18F‐AV‐1451 tau PET retention patterns in early‐and late‐onset Alzheimer's disease. Brain. 2017;140:2286‐2294. - PubMed
-
- Palasí A, Gutiérrez‐Iglesias B, Alegret M, et al. Differentiated clinical presentation of early and late‐onset Alzheimer's disease: is 65 years of age providing a reliable threshold? J Neurol. 2015;262:1238‐1246. - PubMed
LinkOut - more resources
Full Text Sources