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. 2024 Apr 9;10(8):e29263.
doi: 10.1016/j.heliyon.2024.e29263. eCollection 2024 Apr 30.

DRI Triton SS-OCT applied to detect choroidal nodules in paediatric patients affected by NF1

Carlos Fresno Cañada  1   2 , Joan Gispets Parcerisas  1 , Cristina Del Prado Sánchez  3 , Enric Puigventós Rosanas  3 , Sara Perez-Jaume  4 , Héctor Salvador  5 , Ana Llorca Cardeñosa  6 , Joan Prat Bartomeu  7
Affiliations

DRI Triton SS-OCT applied to detect choroidal nodules in paediatric patients affected by NF1

Carlos Fresno Cañada et al. Heliyon. .

Abstract

Purpose: To examine whether image processing of non-mydriatic DRI Triton SS-OCT (Topcon Corporation, Tokyo, Japan) using the red free filter could assess the presence of choroidal nodules and thus include their detection as a diagnostic criterion in neurofibromatosis type 1 (NF1).

Material and methods: We included 417 eyes from 210 patients, 377 - from 190 patients diagnosed with NF1 according to the criteria established by the National Institutes of Health Consensus Development Conference (NIH) and 40 from 20 healthy patients as a control group. The mean age was 9.4 years (range 2 years-18 years). All patients had their visual acuity measured by a test according to age, were examined for the presence of lisch nodules and an Optical Coherence Tomography (OCT) of the macular area was performed. All the OCT images were analysed to check if visible nodules could be identified.

Results: Ages 14 (95% CI=(9.7,18.3)) and 12 years (95% CI=(9.1,14)) are the cut-off points that best separate those with choroidal nodules with Triton OCT and lisch with slit lamp, respectively, from those without. lisch nodules were detected in 50% of cases of NF1 patients. The presence of choroidal nodules did not present a statistically significant correlation with the occurrence of optic pathway glioma (p = 0.96) nor with the patient's visual worsening (p = 0.072). A statistically significant correlation was observed between the presence of choroidal nodules and the presence of lisch nodules (p < 0.05).

Conclusion: The Topcon Triton OCT red free tool would not be a good tool to detect choroidal nodules in patients with NF1 because of its low sensitivity. If the presence of choroidal nodules were to be included in the diagnostic criteria for NF1, it would be convenient to use a device with red and infrared radiations.

Keywords: Choroidal nodules; Lisch nodules; Neurofibromatosis 1; Paediatrics; Visual acuity.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Joan Gispets Parcerisas reports financial support and article publishing charges were provided by 10.13039/501100014374Polytechnic University of Catalonia. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Graph 1
Graph 1
Graph of densities with cut point for choroidal nodules.
Graph 2
Graph 2
Graph densities with cut point for Lisch nodules.
Graph 3
Graph 3
Boxplot: VA logMar according to choroidal nodules presence.
Image 1
Image 1
Triton OCT DRI Triton SS-OCT with RED FREE filter on a patient presenting choroidal nodules. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

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