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Review
. 2024 Apr 18.
doi: 10.1007/s11010-024-04997-z. Online ahead of print.

Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease

Meiling Cao #  1 , Yanshan Liu #  2 , Ying Sun  2 , Ruiyi Han  2 , Hongkun Jiang  3
Affiliations
Review

Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease

Meiling Cao et al. Mol Cell Biochem. .

Abstract

Congenital heart disease (CHD) represents a significant risk factor with profound implications for neonatal survival rates and the overall well-being of adult patients. The emergence of induced pluripotent stem cells (iPSCs) and their derived cells, combined with CRISPR technology, high-throughput experimental techniques, and organoid technology, which are better suited to contemporary research demands, offer new possibilities for treating CHD. Prior investigations have indicated that the paracrine effect of exosomes may hold potential solutions for therapeutic intervention. This review provides a summary of the advancements in iPSC-based models and clinical trials associated with CHD while elucidating potential therapeutic mechanisms and delineating clinical constraints pertinent to iPSC-based therapy, thereby offering valuable insights for further deliberation.

Keywords: Clinical trials; Congenital heart disease; Disease modeling; Exosomes; Induced pluripotent stem cells; hiPSC therapy.

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