Babesia duncani, A Model Organism for Investigating Intraerythrocytic Parasitism and Novel Anti-Parasitic Therapeutic Strategies
- PMID: 38626187
- DOI: 10.1093/infdis/jiae191
Babesia duncani, A Model Organism for Investigating Intraerythrocytic Parasitism and Novel Anti-Parasitic Therapeutic Strategies
Abstract
Pathogens such as Plasmodium, Babesia, and Theileria invade and multiply within host red blood cells, leading to the pathological consequences of malaria, babesiosis and theileriosis. Establishing continuous in vitro culture systems and suitable animal models is crucial for studying these pathogens. This review spotlights the B. duncani "in culture-in mouse (ICIM)" model as a promising resource for advancing research on the biology, pathogenicity, and virulence of intraerythrocytic parasites. The model offers practical benefits, encompassing well-defined culture conditions, ease of manipulation and a well-annotated genome. Moreover, B. duncani serves as a surrogate system for drug discovery, facilitating the evaluation of new antiparasitic drugs in vitro and in animals, elucidating their modes of action, and uncovering potential resistance mechanisms. The B. duncani ICIM model thus emerges as a multifaceted tool with profound implications, promising advancements in our understanding of parasitic biology and shaping the development of future therapies.
Keywords: Babesia; Parasite; Plasmodium; Theileria; Therapy; drugs; in vitro culture; mouse model.
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
Similar articles
-
Babesia duncani in Culture and in Mouse (ICIM) Model for the Advancement of Babesia Biology, Pathogenesis, and Therapy.Bio Protoc. 2022 Nov 20;12(22):e4549. doi: 10.21769/BioProtoc.4549. eCollection 2022 Nov 20. Bio Protoc. 2022. PMID: 36620533 Free PMC article.
-
Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo.J Infect Dis. 2022 Sep 28;226(7):1267-1275. doi: 10.1093/infdis/jiac181. J Infect Dis. 2022. PMID: 35512141 Free PMC article.
-
Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies.J Biol Chem. 2018 Dec 28;293(52):19974-19981. doi: 10.1074/jbc.AC118.005771. Epub 2018 Nov 21. J Biol Chem. 2018. PMID: 30463941 Free PMC article.
-
Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?Int J Parasitol. 2019 Feb;49(2):183-197. doi: 10.1016/j.ijpara.2018.11.002. Epub 2019 Jan 26. Int J Parasitol. 2019. PMID: 30690089 Free PMC article. Review.
-
Comparative Bioinformatics Analysis of Transcription Factor Genes Indicates Conservation of Key Regulatory Domains among Babesia bovis, Babesia microti, and Theileria equi.PLoS Negl Trop Dis. 2016 Nov 10;10(11):e0004983. doi: 10.1371/journal.pntd.0004983. eCollection 2016 Nov. PLoS Negl Trop Dis. 2016. PMID: 27832060 Free PMC article. Review.
LinkOut - more resources
Full Text Sources