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Case Reports
. 2024 Jul 1;46(7):439-442.
doi: 10.1097/DAD.0000000000002705. Epub 2024 Apr 4.

Spiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases

Ailish Hanly  1 , Noel Turner  2   3 , Christine J Ko  1   3 , Gauri Panse  1   3
Affiliations
Case Reports

Spiny Keratoderma: Clinical and Histopathological Findings in a Series of 3 Cases

Ailish Hanly et al. Am J Dermatopathol. .

Abstract

Spiny keratoderma is a rare entity presenting with minute keratotic spines on the palms and soles. Spiny keratoderma can be inherited or acquired, and the acquired form may be associated with underlying malignancy or systemic disease. Clinically, the differential diagnosis includes other digitate keratoses on acral sites, most notably arsenical keratosis, filiform verruca, and punctate porokeratosis. Biopsy findings typically include a column of parakeratosis overlying a diminished granular cell layer. In this article, we present 3 cases of acquired spiny keratoderma in patients with various systemic diseases, but no underlying malignancy.

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Conflict of interest statement

The authors declare no conflicts of interest.

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References

    1. Metze D, Oji V. Palmoplantar keratodermas. In: Bolognia SJJL, Cerroni L, eds. Dermatology. Philadelphia, PA: Elsevier; 2018.
    1. Brown FC. Punctate keratoderma. Arch Dermatol. 1971;104:682–683.
    1. Chee SN, Ge L, Agar N, et al. Spiny keratoderma: case series and review. Int J Dermatol. 2017;56:915–919.
    1. Caccetta TP, Dessauvagie B, McCallum D, et al. Multiple minute digitate hyperkeratosis: a proposed algorithm for the digitate keratoses. J Am Acad Dermatol. 2012;67:e49–e55.
    1. Hashimoto K, Toi Y, Horton S, et al. Spiny keratoderma--a demonstration of hair keratin and hair type keratinization. J Cutan Pathol. 1999;26:25–30.

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