Effect of Remimazolam- versus Propofol-Based Total Intravenous General Anesthesia on Intraoperative Hemodynamic Stability for Major Spine Surgery in the Prone Position: A Randomized Controlled Trial
- PMID: 38541158
- PMCID: PMC10972152
- DOI: 10.3390/medicina60030432
Effect of Remimazolam- versus Propofol-Based Total Intravenous General Anesthesia on Intraoperative Hemodynamic Stability for Major Spine Surgery in the Prone Position: A Randomized Controlled Trial
Abstract
Background and Objectives: Remimazolam offers advantages over propofol in terms of hemodynamic stability. However, it remains unclear whether remimazolam-based total intravenous anesthesia (TIVA) can reduce intraoperative hypotension compared to propofol-based TIVA, especially after prone positioning. In this study, we compared the effects of remimazolam- and propofol-based TIVA on intraoperative hemodynamic stability in patients undergoing surgery in the prone position. Materials and Methods: This study randomly assigned patients undergoing major spinal surgery in the prone position to the propofol or remimazolam group. Target-controlled infusion (2-3.5 μg/mL for induction and 2-3 μg/mL for maintenance) was used in the propofol group and continuous infusion (6 mg/kg/h for induction and 1-2 mg/kg/h for maintenance) was used in the remimazolam group; target-controlled infusion (3-5 ng/mL) of remifentanil was performed in both groups. The primary outcomes were the incidence of hypotensive episodes during the first hour after prone positioning. The secondary outcomes included the incidence of severe hypotension and the total amount of inotropic or vasopressor medication. Systolic and mean arterial pressure, heart rate, cardiac index and output, stroke volume, stroke volume variation, and pleth variability index were also evaluated. These variables were recorded per minute for the first 10 min after prone positioning, and every 10 min thereafter. Results: The study enrolled 94 patients (47 patients in each group). The incidence of hypotension or severe hypotension did not differ significantly between the two groups during the first hour after prone positioning. The total amount of ephedrine administered during the first hour after prone positioning was lesser (p = 0.020) and the mean arterial pressure during the initial 10 min after prone positioning was higher in the remimazolam group (p = 0.003). Conclusions: Our study uncovered no significant differences in the incidence of hypotension between remimazolam- and propofol-based TIVA in patients undergoing major spine surgery in prone position.
Keywords: perioperative hypotension; prone position; propofol; remimazolam; spinal surgery.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10972152/bin/medicina-60-00432-g001.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10972152/bin/medicina-60-00432-g002.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10972152/bin/medicina-60-00432-g003a.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10972152/bin/medicina-60-00432-g003a.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10972152/bin/medicina-60-00432-g004a.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10972152/bin/medicina-60-00432-g004a.gif)
Similar articles
-
Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: a single-center, randomized, controlled trial.BMC Anesthesiol. 2023 Jan 10;23(1):14. doi: 10.1186/s12871-023-01974-9. BMC Anesthesiol. 2023. PMID: 36624371 Free PMC article. Clinical Trial.
-
Comparison of remimazolam-based and propofol-based total intravenous anesthesia on hemodynamics during anesthesia induction in patients undergoing transcatheter aortic valve replacement: a randomized controlled trial.J Anesth. 2024 Jun;38(3):330-338. doi: 10.1007/s00540-024-03311-x. Epub 2024 Feb 12. J Anesth. 2024. PMID: 38347233 Clinical Trial.
-
Hypotension after general anaesthesia induction using remimazolam or propofol in geriatric patients undergoing sevoflurane anaesthesia with remifentanil: a single-centre, double-blind, randomised controlled trial.Br J Anaesth. 2024 Jul;133(1):24-32. doi: 10.1016/j.bja.2024.04.013. Epub 2024 May 22. Br J Anaesth. 2024. PMID: 38777646 Clinical Trial.
-
Efficacy of remimazolam tosilate versus propofol for total intravenous anaesthesia in urological surgery: A randomised clinical trial.Eur J Anaesthesiol. 2024 Mar 1;41(3):208-216. doi: 10.1097/EJA.0000000000001938. Epub 2024 Jan 2. Eur J Anaesthesiol. 2024. PMID: 38165145 Clinical Trial.
-
Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.Cochrane Database Syst Rev. 2018 Aug 21;8(8):CD012317. doi: 10.1002/14651858.CD012317.pub2. Cochrane Database Syst Rev. 2018. PMID: 30129968 Free PMC article. Review.
Cited by
-
Comparison of Hemodynamic Parameters Based on the Administration of Remimazolam or Sevoflurane in Patients under General Anesthesia in the Beach Chair Position: A Single-Blinded Randomized Controlled Trial.J Clin Med. 2024 Apr 18;13(8):2364. doi: 10.3390/jcm13082364. J Clin Med. 2024. PMID: 38673637 Free PMC article.
References
-
- Roshanov P.S., Sheth T., Duceppe E., Tandon V., Bessissow A., Chan M.T.V., Butler C., Chow B.J.W., Khan J.S., Devereaux P.J. Relationship between Perioperative Hypotension and Perioperative Cardiovascular Events in Patients with Coronary Artery Disease Undergoing Major Noncardiac Surgery. Anesthesiology. 2019;130:756–766. doi: 10.1097/ALN.0000000000002654. - DOI - PubMed
-
- Walsh M., Devereaux P.J., Garg A.X., Kurz A., Turan A., Rodseth R.N., Cywinski J., Thabane L., Sessler D.I. Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery: Toward an empirical definition of hypotension. Anesthesiology. 2013;119:507–515. doi: 10.1097/ALN.0b013e3182a10e26. - DOI - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical