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. 2024 Mar 11:17:581-591.
doi: 10.2147/CCID.S438642. eCollection 2024.

Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

Anupam Trehan  1 , Rachna Anand  1 , Garima Chaudhary  1 , Himanshi Garg  1 , Manoj Kumar Verma  1
Affiliations

Efficacy and Safety of Skin Radiance Collagen on Skin and Hair Matrix: A Placebo-Controlled Clinical Trial in Healthy Human Subjects

Anupam Trehan et al. Clin Cosmet Investig Dermatol. .

Abstract

Purpose: Collagen supplements are rising in the market as collagen has been demonstrated to be an important protein in the human aging process. Also, it is safe and easily absorbed in the body. Hence the aim of this study was to examine the effectiveness and safety of a collagen and antioxidant-rich treatment compared to a placebo in relation to various skin and hair indicators in healthy adult human subjects.

Patients and methods: Forty healthy adult non-pregnant/non-lactating women (aged 38-50 years) provided their informed consent in writing before their participation. Skin Radiance Collagen (SRC) treatment and a placebo were assessed for efficacy before application on Day 1, and post-application on Days 28 and 56, to measure changes in skin elasticity, hydration, brightness, pigmentation; texture, wrinkles, dryness, smoothness, fine lines, changes in the crow's feet region; as well as hair strength and hair fall.

Results: It was observed after 56 days that therapy with SRC, compared to placebo, produced a substantial effect on reduction of wrinkle depth and fine lines by 48.11% and 39%, respectively, with p-value <0.01 in the test group. There was a 15.69% improvement in skin hydration observed and 28% reduction in hair fall with p-value <0.01.

Conclusion: SRC, a combination of collagen with hyaluronic acid (HA), biotin, and vitamins C and E, showed a significant improvement in skin and hair health, including improvements in skin elasticity, skin hydration, reduction in crow's feet area wrinkles and fine lines, hair fall, and decrease in roughness, leading to improved skin texture. Vitamin C in the formulation also acts as a collagen builder for the body and helps in preventing oxidative stress in the body. The test treatment SRC was found to be efficacious and safe in healthy human adult subjects.

Keywords: crow’s feet wrinkles; hair fall reduction; skin elasticity; skin hydration; skin roughness.

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Conflict of interest statement

The authors affirm that no associations have influenced the work reported in this paper. The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Study Flow Diagram.
Figure 2
Figure 2
Reduction of Hair Fall from Baseline to Post Baseline for Placebo (Powder) and Test Treatment Group (Skin Radiance Collagen).
Figure 3
Figure 3
3D Images of Crow’s Feet Area Wrinkles of Subject Number 003 Before and After Consuming Test Treatment. (A) Prevalent blue colour lines indicating the depth of wrinkles on Day 01, before consuming treatment; (B) Reduction in blue colour lines indicating an overall improvement in wrinkles on Day 56, after treatment with Skin Radiance Collagen.
Figure 4
Figure 4
Photographs of Crow’s Feet Area Wrinkles of Three Different Subjects Before and After Consuming Test Treatment. (A) Existing wrinkles of subject number 006 on Day 01, before treatment; (B) Decrease in wrinkles of subject number 006 on Day 56, after test treatment consumption; (C) Existing wrinkles of subject number 003 on Day 01, before treatment; (D) Decrease in wrinkles of subject number 003 on Day 56, after test treatment consumption; (E) Existing wrinkles of subject number 004 on Day 01, before treatment; (F) Decrease in wrinkles of subject number 004 on Day 56, after test treatment consumption.
Figure 5
Figure 5
Improvement in Skin Roughness Pre and Post Consuming Placebo (Powder) and Test Treatment (Skin Radiance Collagen).
Figure 6
Figure 6
Improvement in Glogau Skin Age Pre and Post Consuming Test Treatment (Skin Radiance Collagen; image A) and Placebo (Powder; image B). (A) From total 19 subjects, 13 subjects experienced improvement from Glogau skin type III (before test treatment consumption on Day 01) to skin type II (after test treatment consumption on Day 56); (B) From total 18 subjects, only 1 subject with Glogau skin type III (on Day 01) experienced improvement to skin type II (on Day 56), after consumption of placebo.
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