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. 2023 Aug 11;22(2):75-80.
doi: 10.1080/2090598X.2023.2245598. eCollection 2024.

Dapoxetine versus glans penis injection with hyaluronic acid gel in treatment of premature ejaculation

Ibrahim M Ibrahim  1 , Moustafa Mohamed  1 , Mostafa Kamel  1 , Lotfy Elbendary  1 , Almaqtouf Mohamed  2 , Mohamed S Elderey  1
Affiliations

Dapoxetine versus glans penis injection with hyaluronic acid gel in treatment of premature ejaculation

Ibrahim M Ibrahim et al. Arab J Urol. .

Abstract

Objective: to compare the results of using Dapoxetine and HA (hyaluronic acid) gel injection by Five puncture technique in the treatment of premature ejaculation (PE).

Methods: 100 sexually active heterosexuals circumcised males with lifelong PE were included in the study. Group A patients were treated with on-demand Dapoxetine, while group B was treated with HA gel glans penis injection using a five-puncture technique. Both groups were evaluated at 1st,3rd and 6th months post-treatment using IELT.

Results: There were no significant differences between both groups regarding patient demographic. Mean pretreatment IELT in groups A and B were 45.82 ± 7.44 and 46.18 ± 7.82 receptively. There was no significant difference between both groups. After treatment, both groups show significant ILET improvement during the 1st,3rd, and 6th months follow-up with a P value < 0.001. However, when comparing the improvement of ILET in group A (Dapoxetine) and group B (HA injection), there were high significance differences in favor of group B in the 1st,3rd, and 6th-month follow-up.

Conclusion: Although both treatment modalities have improved IELT and premature ejaculation, but HA injection with five punctures technique was significantly better than oral Dapoxetine with self-limited side effects.

Keywords: Dapoxetine; Hyaluronic Acid Gel; premature ejaculation and glans penis injection.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Total number of patient in each group.
Figure 2.
Figure 2.
5 puncture technique Sakr a et al 2022(10).
Figure 3.
Figure 3.
Difference in IELT among both studied groups post-treatment.
See this image and copyright information in PMC

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