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. 2024 Feb 24;14(5):711.
doi: 10.3390/ani14050711.

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study

Aliénor Delsart  1 , Colombe Otis  1 , Vivian S Y Leung  1 , Émilie Labelle  1 , Maxim Moreau  1   2 , Marilyn Frezier  1 , Marlene Drag  3 , Johanne Martel-Pelletier  2 , Jean-Pierre Pelletier  2 , Eric Troncy  1   2
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Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study

Aliénor Delsart et al. Animals (Basel). .

Abstract

Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (n = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They were assessed during Baseline, Treatment, and Recovery periods using MI-CAT(V) and objective outcomes (effort path, stairs assay compliance, and actimetry). The MI-CAT(V) total score correlated to the effort path and actimetry (RhoS = -0.501 to -0.453; p < 0.001), also being sensitive to treatment responsiveness. The pooled treatment group improved its total, gait, and body posture scores during Treatment compared to the Baseline, Recovery, and placebo group (p < 0.05). The MI-CAT(V) suggested a dose-(especially for Gr. B) and cluster-response. Cats in the moderate and severe MI-CAT(V) clusters responded to firocoxib with a remaining analgesic effect, while the mild cluster seemed less responsive and experienced a negative rebound effect. The MI-CAT(V) was validated for its OA pain severity discriminatory abilities and sensitivity to firocoxib treatment, providing a new perspective for individualized care.

Keywords: actimetry; feline; firocoxib; metrology; osteoarthritis; pain scale.

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Conflict of interest statement

The authors declare no conflicts of interest in the development of this research project. M.D. is a regular employee of Boehringer Ingelheim Animal Health, Inc.; M.M. is a regular employee of ArthroLab, Inc.

Figures

Figure 1
Figure 1
MI-CAT(V) total score evolution of the different groups during Baseline, Treatment, and Recovery periods.
Figure 2
Figure 2
NAM sum values per hour evolution of both groups.
Figure 3
Figure 3
MI-CAT(V) evolution of the gait and body posture sub-sections.
Figure 4
Figure 4
Within-time evolution of the MI-CAT(V) total score for each cluster.
See this image and copyright information in PMC

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