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Review
. 2024 Mar 12;51(1):415.
doi: 10.1007/s11033-024-09374-z.

Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders

Javed Iqbal  1 , Geng-Di Huang  1 , Yan-Xue Xue  2 , Mei Yang  3   4   5 , Xiao-Jian Jia  6   7   8
Affiliations
Review

Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders

Javed Iqbal et al. Mol Biol Rep. .

Abstract

Estrogen regulates a wide range of neuronal functions in the brain, such as dendritic spine formation, remodeling of synaptic plasticity, cognition, neurotransmission, and neurodevelopment. Estrogen interacts with intracellular estrogen receptors (ERs) and membrane-bound ERs to produce its effect via genomic and non-genomic pathways. Any alterations in these pathways affect the number, size, and shape of dendritic spines in neurons associated with psychiatric diseases. Increasing evidence suggests that estrogen fluctuation causes changes in dendritic spine density, morphology, and synapse numbers of excitatory and inhibitory neurons differently in males and females. In this review, we discuss the role of estrogen hormone in rodents and humans based on sex differences. First, we explain estrogen role in learning and memory and show that a high estrogen level alleviates the deficits in learning and memory. Secondly, we point out that estrogen produces a striking difference in emotional memories in men and women, which leads them to display sex-specific differences in underlying neuronal signaling. Lastly, we discuss that fluctuations in estrogen levels in men and women are related to neuropsychiatric disorders, including schizophrenia, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder (BPD), major depressive disorder (MDD), substance use disorder (SUD), and anxiety disorders.

Keywords: Dendritic spines; Drug addiction; Estrogen; Memory.

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References

    1. Almey A, Milner TA, Brake WG (2015) Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females. Horm Behav 74:125–138 - PubMed - PMC - DOI
    1. Waters EM et al (2011) Estrogen and aging affect the synaptic distribution of estrogen receptor beta-immunoreactivity in the CA1 region of female rat hippocampus. Brain Res 1379:86–97 - PubMed - DOI
    1. Mitra SW et al (2003) Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha. Endocrinology 144(5):2055–2067 - PubMed - DOI
    1. Mazid S et al (2023) Both nuclear and membrane estrogen receptor alpha impact the expression of estrogen receptors and plasticity markers in the mouse hypothalamus and hippocampus. Biology (Basel) 12(4):632 - PubMed - PMC
    1. Wang YX et al (2019) Postnatal expression patterns of estrogen receptor subtypes and choline acetyltransferase in different regions of the Papez circuit. Dev Neurosci 41(3–4):203–211 - PubMed - DOI