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Editorial
. 2024 Jan 26;383(6681):349.
doi: 10.1126/science.ado1671. Epub 2024 Jan 25.

Protein design meets biosecurity

David Baker  1 , George Church  2
Affiliations
Editorial

Protein design meets biosecurity

David Baker et al. Science. .

Abstract

The power and accuracy of computational protein design have been increasing rapidly with the incorporation of artificial intelligence (AI) approaches. This promises to transform biotechnology, enabling advances across sustainability and medicine. DNA synthesis plays a critical role in materializing designed proteins. However, as with all major revolutionary changes, this technology is vulnerable to misuse and the production of dangerous biological agents. To enable the full benefits of this revolution while mitigating risks that may emerge, all synthetic gene sequence and synthesis data should be collected and stored in repositories that are only queried in emergencies to ensure that protein design proceeds in a safe, secure, and trustworthy manner.

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