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. 2024 Aug;310(2):1019-1025.
doi: 10.1007/s00404-023-07331-y. Epub 2024 Jan 9.

Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study

Ting Huang  1 , Fan Lu  2
Affiliations

Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study

Ting Huang et al. Arch Gynecol Obstet. 2024 Aug.

Abstract

Purpose: Epidemiological studies examining the association between circulating micronutrients and the risk of hypertensive disorders during pregnancy (HDP) have produced inconsistent results. Therefore, we conducted a Mendelian randomization (MR) analysis to evaluate the potential causal relationship between micronutrients and HDP.

Methods: Nine micronutrients (beta-carotene, vitamin B6, vitamin B12, calcium, zinc, selenium, copper, folate, and phosphorus) were selected as the exposure factors. Summary data for gestational hypertension (14,727 cases and 196,143 controls) and preeclampsia/eclampsia (7212 cases and 174,266 controls) were extracted from the FinnGen consortium. The MR analysis employed the inverse variance weighted method and conducted a range of sensitivity analyses.

Results: The inverse variance weighted method indicated no significant causal relationship between nine genetically predicted micronutrient concentrations and gestational hypertension, as well as preeclampsia/eclampsia. Sensitivity analyses suggested the absence of pleiotropy.

Conclusion: There is no strong evidence to support the causation between circulating micronutrients and hypertensive disorder during pregnancy.

Keywords: Gestational hypertension; Mendelian randomization; Micronutrients; Preeclampsia.

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References

    1. Kassebaum NJ, Bertozzi-Villa A, Coggeshall MS et al (2014) Global, regional, and national levels and causes of maternal mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384:980–1004. https://doi.org/10.1016/S0140-6736(14)60696-6 - DOI - PubMed - PMC
    1. Ahsan T, Banu S, Nahar Q et al (2013) Serum trace elements levels in preeclampsia and eclampsia: correlation with the pregnancy disorder. Biol Trace Elem Res 152:327–332. https://doi.org/10.1007/s12011-013-9637-4 - DOI - PubMed
    1. Chen Y, Ou QX, Chen Y et al (2022) Association between trace elements and preeclampsia: a retrospective cohort study. J Trace Elem Med Biol 72:126971. https://doi.org/10.1016/j.jtemb.2022.126971 - DOI - PubMed
    1. Kang T, Liu Y, Chen X et al (2022) Dietary carotenoid intake and risk of developing preeclampsia: a hospital-based case-control study. BMC Pregnancy Childbirth 22:427. https://doi.org/10.1186/s12884-022-04737-5 - DOI - PubMed - PMC
    1. Bodnar LM, Kirkpatrick SI, Roberts JM et al (2023) Is the association between fruits and vegetables and preeclampsia due to higher dietary vitamin C and carotenoid intakes? Am J Clin Nutr 118:459–467. https://doi.org/10.1016/j.ajcnut.2023.06.007 - DOI - PubMed - PMC

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