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Review
. 2023 Nov 29:12:248.
doi: 10.4103/abr.abr_259_22. eCollection 2023.

Genetic Susceptibility to Fungal Infections

Mohammad Yazdi  1 , Nima Behnaminia  2 , Amirhossein Nafari  3 , Asghar Sepahvand  4
Affiliations
Review

Genetic Susceptibility to Fungal Infections

Mohammad Yazdi et al. Adv Biomed Res. .

Abstract

Reports of fungal infections have increased over the past decades, making them a major threat to human health. In this study, we review the effects of genetic defects on susceptibility to fungal diseases. To identify all relevant literature, we searched Google Scholar, PubMed, and Scopus and profiled studies published between 2008 and 2021. The results of several studies conducted on this subject have shown the significant effects of genetic variations such as hyper-IgE syndrome, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome, dectin-1 deficiency, CARD9 mutations, STAT1 mutations, and IL17 mutationson the host immune system's response, which has an important impact on susceptibility to fungal infections. The underlying immune system-related genetic profile affects the susceptibility of individuals to different fungal infections; therefore, this subject should be further studied for better treatment of fungal diseases.

Keywords: Fungal infections; genetic diseases; immune system.

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Conflict of interest statement

There are no conflicts of interest.

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