Mendelian randomization study of lipid metabolism characteristics and migraine risk
- PMID: 38183343
- DOI: 10.1002/ejp.2235
Mendelian randomization study of lipid metabolism characteristics and migraine risk
Abstract
Background: The association between serum lipids and migraine is controversial. However, randomized controlled trials have suggested that statins may be efficacious for the prevention of migraine. In this study, we aim to investigate the relationship between lipids metabolism and migraine risk.
Methods: Single-nucleotide polymorphisms (SNPs), relating to the serum lipid traits and the effect of lipid-lowering drugs that target APOB, CETP, HMGCR, NPC1L1, and PCSK9, were extracted from genome-wide association studies (GWAS) summary data. The GWAS summary data were obtained from the Global Lipids Genetic Consortium (GLGC), the UK Biobank, and the FinnGen study, respectively. Mendelian randomization (MR) analysis was performed to evaluate the association between serum lipid traits and lipid-lowering drugs with migraine risk.
Results: Regarding serum lipids, it was found that SNPs related to high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), total cholesterol (TC), or triglycerides (TG) levels were not associated with migraine, migraine with aura (MA) or migraine without aura (MO). In addition, genotypes of HMGCR related to higher LDL-C levels were associated with increased risk of migraine (OR = 1.46, p = 0.035) and MA (OR = 2.03, p = 0.008); However, genotypes of PCSK9 related to higher LDL-C levels were associated with decreased risk of migraine (OR = 0.75, p = 0.001) and MA (OR = 0.69, p = 0.004); And genotypes of APOB related to higher LDL-C levels were associated with decreased risk of MO (OR = 0.62, p = 0.000).
Conclusions: There is a relationship between lipid metabolism characteristics and migraine risk.
Significance: Based on the genome-wide association summary data, single-nucleotide polymorphisms (SNPs) related to high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), total cholesterol (TC), or triglycerides (TG) level were not associated with risk of migraine, migraine with aura (MA) or migraine without aura (MO). However, genotypes of HMGCR related to higher LDL-C levels have shown an increased risk on migraine and MA. And genotypes of APOB or PCSK9 related to higher LDL-C levels have shown a decreased risk on MO, or migraine and MA, respectively. These results suggested that there may be a relationship between lipid metabolism characteristics and the risk for migraine development.
© 2024 European Pain Federation ‐ EFIC ®.
Similar articles
-
Effects of genetically proxied lipid-lowering drugs on acute myocardial infarction: a drug-target mendelian randomization study.Lipids Health Dis. 2024 Jun 3;23(1):163. doi: 10.1186/s12944-024-02133-w. Lipids Health Dis. 2024. PMID: 38831433 Free PMC article.
-
Associations of Lipids and Lipid-Lowering Drugs with Risk of Vascular Dementia: A Mendelian Randomization Study.Nutrients. 2022 Dec 23;15(1):69. doi: 10.3390/nu15010069. Nutrients. 2022. PMID: 36615727 Free PMC article.
-
Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.PLoS Genet. 2021 Apr 22;17(4):e1009525. doi: 10.1371/journal.pgen.1009525. eCollection 2021 Apr. PLoS Genet. 2021. PMID: 33886544 Free PMC article.
-
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.PLoS Med. 2020 Mar 23;17(3):e1003062. doi: 10.1371/journal.pmed.1003062. eCollection 2020 Mar. PLoS Med. 2020. PMID: 32203549 Free PMC article.
-
Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.JAMA Cardiol. 2018 Jan 1;3(1):26-33. doi: 10.1001/jamacardio.2017.4293. JAMA Cardiol. 2018. PMID: 29188294 Free PMC article. Review.
References
REFERENCES
-
- 2016 Global Burden of Disease Study. (2017). Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet (London, England), 390, 1211–1259.
-
- 2016 Global Burden of Disease Study. (2018). Global, regional, and national burden of migraine and tension‐type headache, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet Neurology, 17, 954–976.
-
- Ailani, J., Burch, R. C., & Robbins, M. S. (2021). The American headache society consensus statement: Update on integrating new migraine treatments into clinical practice. Headache, 61, 1021–1039.
-
- Banach, M., Serban, C., Ursoniu, S., Rysz, J., Muntner, P., Toth, P. P., Jones, S. R., Rizzo, M., Glasser, S. P., Watts, G. F., Blumenthal, R. S., Lip, G. Y., Mikhailidis, D. P., & Sahebkar, A. (2015). Statin therapy and plasma coenzyme Q10 concentrations—A systematic review and meta‐analysis of placebo‐controlled trials. Pharmacological Research, 99, 329–336.
-
- Banerjee, S., & De, A. (2021). Pathophysiology and inhibition of cholesteryl ester transfer protein for prevention of cardiovascular diseases: An update. Drug Discovery Today, 26, 1759–1764.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous