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Review
. 2023 Nov 28;12(12):1399.
doi: 10.3390/pathogens12121399.

Diagnosis in Scrapie: Conventional Methods and New Biomarkers

Diego Sola  1 , Marina Betancor  1 , Paula A Marco Lorente  1 , Sonia Pérez Lázaro  1 , Tomás Barrio  2 , Eloisa Sevilla  1 , Belén Marín  1 , Bernardino Moreno  1 , Marta Monzón  1 , Cristina Acín  1 , Rosa Bolea  1 , Juan J Badiola  1 , Alicia Otero  1
Affiliations
Review

Diagnosis in Scrapie: Conventional Methods and New Biomarkers

Diego Sola et al. Pathogens. .

Abstract

Scrapie, a naturally occurring prion disease affecting goats and sheep, comprises classical and atypical forms, with classical scrapie being the archetype of transmissible spongiform encephalopathies. This review explores the challenges of scrapie diagnosis and the utility of various biomarkers and their potential implications for human prion diseases. Understanding these biomarkers in the context of scrapie may enable earlier prion disease diagnosis in humans, which is crucial for effective intervention. Research on scrapie biomarkers bridges the gap between veterinary and human medicine, offering hope for the early detection and improved management of prion diseases.

Keywords: PrPSc; prion biomarkers; prion diseases; scrapie.

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Conflict of interest statement

The authors declare no conflict of interest.

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