The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases
- PMID: 38087167
- DOI: 10.1007/s12035-023-03841-7
The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases
Abstract
Mitochondrial transcription factor A (TFAM) is a mitochondrial protein encoded by nuclear genes and transported from the cytoplasm to the mitochondria. TFAM is essential for the maintenance, expression, and delivery of mitochondrial DNA (mtDNA) and can regulate the replication and transcription of mtDNA. TFAM is associated with the formation of mtDNA nucleomimetic structures, mtDNA repair, and mtDNA stability. However, the mechanism by which TFAM protects mtDNA is still being studied. This review provides a summary of the protective mechanism of TFAM on mtDNA including the discrete regulatory effects of TFAM acetylation and phosphorylation on mtDNA, the regulation of Ca2+ levels by TFAM to activate transcription in mitochondria, and the increased binding of TFAM to mtDNA damage hot spots. This review also discusses the association between TFAM and some neurodegenerative diseases.
Keywords: Mitochondria; Mitochondrial DNA; Mitochondrial transcription factor A; Neurodegenerative diseases.
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
-
The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms.FEBS Lett. 2018 Mar;592(5):793-811. doi: 10.1002/1873-3468.12989. Epub 2018 Feb 15. FEBS Lett. 2018. PMID: 29364506 Free PMC article. Review.
-
Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number.Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):921-9. doi: 10.1016/j.bbagrm.2012.03.002. Epub 2012 Mar 21. Biochim Biophys Acta. 2012. PMID: 22465614 Review.
-
Gene Editing Technologies Targeting TFAM and Its Relation to Mitochondrial Diseases.Adv Exp Med Biol. 2023;1429:173-189. doi: 10.1007/978-3-031-33325-5_10. Adv Exp Med Biol. 2023. PMID: 37486522
-
Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA.Mol Cell Biol. 2004 Nov;24(22):9823-34. doi: 10.1128/MCB.24.22.9823-9834.2004. Mol Cell Biol. 2004. PMID: 15509786 Free PMC article.
-
Regulation of mitochondrial gene expression, the epigenetic enigma.Front Biosci (Landmark Ed). 2017 Mar 1;22(7):1099-1113. doi: 10.2741/4535. Front Biosci (Landmark Ed). 2017. PMID: 28199194 Review.
Cited by
-
SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats.Pflugers Arch. 2024 Jul;476(7):1125-1143. doi: 10.1007/s00424-024-02967-4. Epub 2024 May 3. Pflugers Arch. 2024. PMID: 38700719 Free PMC article.
-
Involvement of Ferroptosis Induction and Oxidative Phosphorylation Inhibition in the Anticancer-Drug-Induced Myocardial Injury: Ameliorative Role of Pterostilbene.Int J Mol Sci. 2024 Mar 5;25(5):3015. doi: 10.3390/ijms25053015. Int J Mol Sci. 2024. PMID: 38474261 Free PMC article.
References
-
- Annesley SJ, Fisher PR (2019) Mitochondria in health and disease. Cells 8(7). https://doi.org/10.3390/cells8070680
-
- Cannino G, Ferruggia E, Luparello C, Rinaldi AM (2009) Cadmium and mitochondria. Mitochondrion 9(6):377–384. https://doi.org/10.1016/j.mito.2009.08.009 - DOI - PubMed
-
- Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial control of genomic instability in cancer. Cancers 13(8). https://doi.org/10.3390/cancers13081914
-
- El-Hattab AW, Scaglia F (2016) Mitochondrial cytopathies. Cell Calcium 60(3):199–206. https://doi.org/10.1016/j.ceca.2016.03.003 - DOI - PubMed
-
- Shi Y, Manis M, Long J, Wang K, Sullivan PM, Remolina Serrano J, Hoyle R, Holtzman DM (2019) Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med 216(11):2546–2561. https://doi.org/10.1084/jem.20190980 - DOI - PubMed - PMC
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous