Circulating Proteins as Diagnostic Markers in Gastric Cancer
- PMID: 38069253
- PMCID: PMC10706891
- DOI: 10.3390/ijms242316931
Circulating Proteins as Diagnostic Markers in Gastric Cancer
Abstract
Gastric cancer (GC) is a highly malignant disease affecting humans worldwide and has a poor prognosis. Most GC cases are detected at advanced stages due to the cancer lacking early detectable symptoms. Therefore, there is great interest in improving early diagnosis by implementing targeted prevention strategies. Markers are necessary for early detection and to guide clinicians to the best personalized treatment. The current semi-invasive endoscopic methods to detect GC are invasive, costly, and time-consuming. Recent advances in proteomics technologies have enabled the screening of many samples and the detection of novel biomarkers and disease-related signature signaling networks. These biomarkers include circulating proteins from different fluids (e.g., plasma, serum, urine, and saliva) and extracellular vesicles. We review relevant published studies on circulating protein biomarkers in GC and detail their application as potential biomarkers for GC diagnosis. Identifying highly sensitive and highly specific diagnostic markers for GC may improve patient survival rates and contribute to advancing precision/personalized medicine.
Keywords: biomarkers; circulating biomarkers; exosomes; gastric cancer; liquid biopsy; plasma proteins; proteomics; saliva proteins; serum proteins; urine proteins.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10706891/bin/ijms-24-16931-g001.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/10706891/bin/ijms-24-16931-g002.gif)
Similar articles
-
Novel biomarkers for early detection of gastric cancer.World J Gastroenterol. 2023 May 7;29(17):2515-2533. doi: 10.3748/wjg.v29.i17.2515. World J Gastroenterol. 2023. PMID: 37213407 Free PMC article. Review.
-
Recent advances in gastric cancer early diagnosis.World J Gastroenterol. 2019 May 7;25(17):2029-2044. doi: 10.3748/wjg.v25.i17.2029. World J Gastroenterol. 2019. PMID: 31114131 Free PMC article. Review.
-
Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy.Mol Biol Rep. 2021 Dec;48(12):8061-8074. doi: 10.1007/s11033-021-06740-z. Epub 2021 Oct 23. Mol Biol Rep. 2021. PMID: 34687392 Free PMC article. Review.
-
New blood markers detection technology: A leap in the diagnosis of gastric cancer.World J Gastroenterol. 2016 Jan 21;22(3):1202-12. doi: 10.3748/wjg.v22.i3.1202. World J Gastroenterol. 2016. PMID: 26811658 Free PMC article. Review.
-
A proteomics based approach for the identification of gastric cancer related markers.Curr Pharm Des. 2016;22(7):804-11. doi: 10.2174/1381612822666151209151848. Curr Pharm Des. 2016. PMID: 26648471 Review.
Cited by
-
Stage-Specific Alteration and Prognostic Relationship of Serum Fumarate Hydratase Autoantibodies in Gastric Cancer.Int J Mol Sci. 2024 May 17;25(10):5470. doi: 10.3390/ijms25105470. Int J Mol Sci. 2024. PMID: 38791507 Free PMC article.
-
Prognosis and Treatment of Gastric Cancer: A 2024 Update.Cancers (Basel). 2024 Apr 27;16(9):1708. doi: 10.3390/cancers16091708. Cancers (Basel). 2024. PMID: 38730659 Free PMC article. Review.
-
Small-Cell Lung Cancer: Is Liquid Biopsy a New Tool Able to Predict the Efficacy of Immunotherapy?Biomolecules. 2024 Mar 25;14(4):396. doi: 10.3390/biom14040396. Biomolecules. 2024. PMID: 38672414 Free PMC article. Review.
-
Predicting early gastric cancer risk using machine learning: A population-based retrospective study.Digit Health. 2024 Mar 22;10:20552076241240905. doi: 10.1177/20552076241240905. eCollection 2024 Jan-Dec. Digit Health. 2024. PMID: 38559579 Free PMC article.
-
The Circulating Biomarkers League: Combining miRNAs with Cell-Free DNAs and Proteins.Int J Mol Sci. 2024 Mar 17;25(6):3403. doi: 10.3390/ijms25063403. Int J Mol Sci. 2024. PMID: 38542382 Free PMC article. Review.
References
-
- Vitelli-Storelli F., Rubín-García M., Pelucchi C., Benavente Y., Bonzi R., Rota M., Palli D., Ferraroni M., Lunet N., Morais S., et al. Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium. Cancers. 2021;13:3844. doi: 10.3390/cancers13153844. - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous