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Review
. 2023 Nov 30;12(23):2745.
doi: 10.3390/cells12232745.

Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties

Paola Baker  1 , Christina Huang  1   2 , Rakan Radi  1 , Samara B Moll  1 , Emmanuela Jules  1 , Jack L Arbiser  3
Affiliations
Review

Skin Barrier Function: The Interplay of Physical, Chemical, and Immunologic Properties

Paola Baker et al. Cells. .

Abstract

An intact barrier function of the skin is important in maintaining skin health. The regulation of the skin barrier depends on a multitude of molecular and immunological signaling pathways. By examining the regulation of a healthy skin barrier, including maintenance of the acid mantle and appropriate levels of ceramides, dermatologists can better formulate solutions to address issues that are related to a disrupted skin barrier. Conversely, by understanding specific skin barrier disruptions that are associated with specific conditions, such as atopic dermatitis or psoriasis, the development of new compounds could target signaling pathways to provide more effective relief for patients. We aim to review key factors mediating skin barrier regulation and inflammation, including skin acidity, interleukins, nuclear factor kappa B, and sirtuin 3. Furthermore, we will discuss current and emerging treatment options for skin barrier conditions.

Keywords: acid mantle; atopic dermatitis; psoriasis; skin barrier.

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Conflict of interest statement

J.L.A. is the co-inventor of [141] for solenopsin and its derivatives, including S12 and S14, which are discussed as Th1 activity stimulators in the manuscript. All other authors have no disclosures to report.

Figures

Figure 1
Figure 1
Interplay between acid, ceramides, and mitochondria and key roles in maintaining skin barrier.
Figure 2
Figure 2
Role of cell senescence signaling in disruption of skin barrier.
See this image and copyright information in PMC

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Grants and funding

This research received no external funding.