Aerobic fitness is a critical aspect of overall health and well-being, essential for maintaining a high quality of life. Unfortunately, sedentary behavior has been on the rise among young adults, and this has had a negative impact on their aerobic fitness levels. Therefore, it is crucial to identify enjoyable physical exercise training programs that can play a pivotal role in improving aerobic fitness. The objective of this study was to systematically review the experimental studies concerning the impact of small-sided games (SSGs) training programs, implemented across various team sports, on the enhancement of aerobic fitness in a youth sedentary population. A literature search was conducted in PubMed, Scopus, and the Web of Science on August 01, 2023. Our eligibility criteria focused on studies involving sedentary youth populations (aged <18 years) as the target population. These studies needed to incorporate interventions based on SSGs as the intervention of interest, comparing them to passive or control groups as the comparator. The primary outcomes of interest were related to maximal oxygen uptake (VO2max), assessed either directly or indirectly, or the results of field-based cardiorespiratory tests. We specifically considered two- or multi-arm randomized controlled studies as the study design of interest. Out of the initial pool of 1980 studies, we reviewed 38 full-text articles, ultimately selecting and analyzing 13 studies for inclusion in our review. Among the studies included, a total of 1281 participants were enrolled in SSG-based interventions, while 744 participants acted as part of the control groups. Regarding the impact on VO2max, the six studies that investigated this outcome showed varying improvements, ranging from 2.2 % to 31.3 % when participants were exposed to SSGs. In terms of the outcome related to endurance performance in field-based tests, the eight studies that examined this aspect found that participants exposed to SSGs showed improvements ranging from 0.1 % to 79.8 %. In conclusion, this systematic review suggests that SSG-based interventions conducted among sedentary youth populations can play a positive role in improving their aerobic fitness. This improvement in aerobic fitness can have potential positive impacts on their overall health and quality of life.