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Review
. 2024 Jan 1:336:122314.
doi: 10.1016/j.lfs.2023.122314. Epub 2023 Nov 27.

An overview of the co-transcription factor NACC1: Beyond its pro-tumor effects

Qing Xie  1 , Chang Tong  2 , Xiangyang Xiong  3
Affiliations
Review

An overview of the co-transcription factor NACC1: Beyond its pro-tumor effects

Qing Xie et al. Life Sci. .

Abstract

Nucleus accumbens-associated protein 1 (NACC1) is a member of the broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) protein families, mainly exerting its biological functions as a transcription co-regulator. NACC1 forms homo- or hetero-dimers through the BTB/POZ or BANP, E5R, and NACC1 (BEN) domain with other transcriptional regulators to regulate downstream signals. Recently, the overexpression of NACC1 has been observed in various tumors and is positively associated with tumor progression, high recurrence rate, indicating poor prognosis. NACC1 also regulates biological processes such as embryonic development, stem cell pluripotency, innate immunity, and related diseases. Our review combines recent research to summarize advancements in the structure, biological functions, and relative molecular mechanisms of NACC1. The future development of NACC1 clinical appliances is also discussed.

Keywords: BEN domain; BTB/POZ domain; NACC1; Transcription co-regulator; Tumor progression.

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Conflict of interest statement

Declaration of competing interest The authors declare no competing interests.

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