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Clinical Trial
. 2024 Feb 10;42(5):571-583.
doi: 10.1200/JCO.23.00339. Epub 2023 Nov 14.

Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in BRCA1 and/or BRCA2 in the PROfound Trial

Joaquin Mateo  1 , Johann S de Bono  2 , Karim Fizazi  3 , Fred Saad  4 , Neal Shore  5 , Shahneen Sandhu  6 , Kim N Chi  7 , Neeraj Agarwal  8 , David Olmos  9 , Antoine Thiery-Vuillemin  10 , Mustafa Özgüroğlu  11 , Niven Mehra  12 , Nobuaki Matsubara  13 , Jae Young Joung  14 , Charles Padua  15 , Ernesto Korbenfeld  16 , Jinyu Kang  17 , Helen Marshall  18 , Zhongwu Lai  19 , Alan Barnicle  20 , Christian Poehlein  21 , Natalia Lukashchuk  20 , Maha Hussain  22
Affiliations
Clinical Trial

Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in BRCA1 and/or BRCA2 in the PROfound Trial

Joaquin Mateo et al. J Clin Oncol. .

Abstract

Olaparib improved PFS and OS across subgroups of BRCA1/2mut #prostatecancer patients in the PROFOUND phase III trial.

Trial registration: ClinicalTrials.gov NCT02987543.

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