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Review
. 2023:34:367-496.
doi: 10.1007/978-3-031-36159-3_9.

Morphological Features of Human Dendritic Spines

Josué Renner  1 , Alberto A Rasia-Filho  1   2
Affiliations
Review

Morphological Features of Human Dendritic Spines

Josué Renner et al. Adv Neurobiol. 2023.

Abstract

Dendritic spine features in human neurons follow the up-to-date knowledge presented in the previous chapters of this book. Human dendrites are notable for their heterogeneity in branching patterns and spatial distribution. These data relate to circuits and specialized functions. Spines enhance neuronal connectivity, modulate and integrate synaptic inputs, and provide additional plastic functions to microcircuits and large-scale networks. Spines present a continuum of shapes and sizes, whose number and distribution along the dendritic length are diverse in neurons and different areas. Indeed, human neurons vary from aspiny or "relatively aspiny" cells to neurons covered with a high density of intermingled pleomorphic spines on very long dendrites. In this chapter, we discuss the phylogenetic and ontogenetic development of human spines and describe the heterogeneous features of human spiny neurons along the spinal cord, brainstem, cerebellum, thalamus, basal ganglia, amygdala, hippocampal regions, and neocortical areas. Three-dimensional reconstructions of Golgi-impregnated dendritic spines and data from fluorescence microscopy are reviewed with ultrastructural findings to address the complex possibilities for synaptic processing and integration in humans. Pathological changes are also presented, for example, in Alzheimer's disease and schizophrenia. Basic morphological data can be linked to current techniques, and perspectives in this research field include the characterization of spines in human neurons with specific transcriptome features, molecular classification of cellular diversity, and electrophysiological identification of coexisting subpopulations of cells. These data would enlighten how cellular attributes determine neuron type-specific connectivity and brain wiring for our diverse aptitudes and behavior.

Keywords: Alzheimer´s disease; Amygdala; Brainstem; Cerebral cortex; Microscopy; Morphology and function; Neural networks; Neuropathology; Postsynaptic processing; Spinal cord; Synapse; Synaptic plasticity; Thalamus.

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References

    1. Acevedo BP, Aron A, Fisher HE et al (2012) Neural correlates of long-term intense romantic love. Soc Cogn Affect Neurosci 7:145–159 - PubMed - DOI
    1. Adolphs R (2003) Is the human amygdala specialized for processing social information? Ann N Y Acad Sci 985:326–340 - PubMed - DOI
    1. Aguilar-Hernández L, Alejandre R, Morales-Medina JC et al (2023) Cellular mechanisms in brain aging: Focus on physiological and pathological aging. J Chem Neuroanat 128:102210. https://doi.org/10.1016/j.jchemneu.2022.102210
    1. Akhmadeev AV, Kalimullina LB (2015) Paleoamygdala: the morphogenesis of nuclear-type, paleocortical and intermediate formations in the perial of postnatal development in rats. Rus J Develop Biol 46:27–32 - DOI
    1. Allman JM, Hakeem A, Erwin JM et al (2001) The anterior cingulate cortex. The evolution of an interface between emotion and cognition. Ann N Y Acad Sci 935:107–117 - PubMed - DOI

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