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Review
. 2023 Nov 7;35(11):1872-1886.
doi: 10.1016/j.cmet.2023.10.011.

Mitohormesis

Yu-Wei Cheng  1 , Jie Liu  1 , Toren Finkel  2
Affiliations
Review

Mitohormesis

Yu-Wei Cheng et al. Cell Metab. .

Abstract

Perturbation of mitochondrial function can trigger a host of cellular responses that seek to restore cellular metabolism, cytosolic proteostasis, and redox homeostasis. In some cases, these responses persist even after the stress is relieved, leaving the cell or tissue in a less vulnerable state. This process-termed mitohormesis-is increasingly viewed as an important aspect of normal physiology and a critical modulator of various disease processes. Here, we review aspects of mitochondrial stress signaling that, among other things, can rewire the cell's metabolism, activate the integrated stress response, and alter cytosolic quality-control pathways. We also discuss how these pathways are implicated in various disease states from pathogen challenge to chemotherapeutic resistance and how their therapeutic manipulation can lead to new strategies for a host of chronic conditions including aging itself.

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Conflict of interest statement

Declaration of interests T.F. is a founder and stockholder in Generian Pharmaceuticals and Coloma Therapeutics and a member of the scientific advisory board of BellSant.

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