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. 2024 Feb;532(2):e25545.
doi: 10.1002/cne.25545. Epub 2023 Oct 17.

Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala

Nandkishore Prakash  1 , Heidi Y Matos  1 , Sonia Sebaoui  1 , Luke Tsai  1 , Tuyen Tran  1 , Adejimi Aromolaran  1 , Isabella Atrachji  1 , Nya Campbell  1 , Meredith Goodrich  1 , David Hernandez-Pineda  1 , Maria Jesus Herrero  1 , Tsutomu Hirata  1 , Julieta Lischinsky  1 , Wendolin Martinez  1 , Shisui Torii  1 , Satoshi Yamashita  1 , Hassan Hosseini  2 , Katie Sokolowski  1 , Shigeyuki Esumi  1 , Yuka Imamura Kawasawa  3 , Kazue Hashimoto-Torii  1 , Kevin S Jones  2   4 , Joshua G Corbin  1
Affiliations

Connectivity and molecular profiles of Foxp2- and Dbx1-lineage neurons in the accessory olfactory bulb and medial amygdala

Nandkishore Prakash et al. J Comp Neurol. 2024 Feb.

Abstract

In terrestrial vertebrates, the olfactory system is divided into main (MOS) and accessory (AOS) components that process both volatile and nonvolatile cues to generate appropriate behavioral responses. While much is known regarding the molecular diversity of neurons that comprise the MOS, less is known about the AOS. Here, focusing on the vomeronasal organ (VNO), the accessory olfactory bulb (AOB), and the medial amygdala (MeA), we reveal that populations of neurons in the AOS can be molecularly subdivided based on their ongoing or prior expression of the transcription factors Foxp2 or Dbx1, which delineate separate populations of GABAergic output neurons in the MeA. We show that a majority of AOB neurons that project directly to the MeA are of the Foxp2 lineage. Using single-neuron patch-clamp electrophysiology, we further reveal that in addition to sex-specific differences across lineage, the frequency of excitatory input to MeA Dbx1- and Foxp2-lineage neurons differs between sexes. Together, this work uncovers a novel molecular diversity of AOS neurons, and lineage and sex differences in patterns of connectivity.

Keywords: Dbx1; Foxp2; accessory olfactory system; medial amygdala; olfactory neuronal diversity; sex differences; vomeronasal organ.

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Conflict of interest statement

Conflict of Interest Statement

The authors declare that there is no conflict of interest.

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