The maternal microbiome promotes placental development in mice
- PMID: 37801498
- PMCID: PMC10558122
- DOI: 10.1126/sciadv.adk1887
The maternal microbiome promotes placental development in mice
Abstract
The maternal microbiome is an important regulator of gestational health, but how it affects the placenta as the interface between mother and fetus remains unexplored. Here, we show that the maternal gut microbiota supports placental development in mice. Depletion of the maternal gut microbiota restricts placental growth and impairs feto-placental vascularization. The maternal gut microbiota modulates metabolites in the maternal and fetal circulation. Short-chain fatty acids (SCFAs) stimulate cultured endothelial cell tube formation and prevent abnormalities in placental vascularization in microbiota-deficient mice. Furthermore, in a model of maternal malnutrition, gestational supplementation with SCFAs prevents placental growth restriction and vascular insufficiency. These findings highlight the importance of host-microbial symbioses during pregnancy and reveal that the maternal gut microbiome promotes placental growth and vascularization in mice.
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Update of
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The maternal microbiome promotes placental development in mice.bioRxiv [Preprint]. 2023 Feb 15:2023.02.15.528712. doi: 10.1101/2023.02.15.528712. bioRxiv. 2023. Update in: Sci Adv. 2023 Oct 6;9(40):eadk1887. doi: 10.1126/sciadv.adk1887. PMID: 36824779 Free PMC article. Updated. Preprint.
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References
-
- M. S. Thion, D. Low, A. Silvin, J. Chen, P. Grisel, J. Schulte-Schrepping, R. Blecher, T. Ulas, P. Squarzoni, G. Hoeffel, F. Coulpier, E. Siopi, F. S. David, C. Scholz, F. Shihui, J. Lum, A. A. Amoyo, A. Larbi, M. Poidinger, A. Buttgereit, P.-M. Lledo, M. Greter, J. K. Y. Chan, I. Amit, M. Beyer, J. L. Schultze, A. Schlitzer, S. Pettersson, F. Ginhoux, S. Garel, Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell 172, 500–516.e16 (2018). - PMC - PubMed
-
- E. D. Watson, J. C. Cross, Development of structures and transport functions in the mouse placenta. Physiology (Bethesda) 20, 180–193 (2005). - PubMed
-
- J. Rossant, J. C. Cross, Placental development: Lessons from mouse mutants. Nat. Rev. Genet. 2, 538–548 (2001). - PubMed
-
- S. Kulandavelu, D. Qu, N. Sunn, J. Mu, M. Y. Rennie, K. J. Whiteley, J. R. Walls, N. A. Bock, J. C. H. Sun, A. Covelli, J. G. Sled, S. L. Adamson, Embryonic and neonatal phenotyping of genetically engineered mice. ILAR J. 47, 103–117 (2006). - PubMed
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