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Review
. 2023 Sep 7;15(18):3897.
doi: 10.3390/nu15183897.

The Effects of Flavonoids on Skeletal Muscle Mass, Muscle Function, and Physical Performance in Individuals with Sarcopenia: A Systematic Review of Randomized Controlled Trials

Cong Wu  1 , Katsuhiko Suzuki  2
Affiliations
Review

The Effects of Flavonoids on Skeletal Muscle Mass, Muscle Function, and Physical Performance in Individuals with Sarcopenia: A Systematic Review of Randomized Controlled Trials

Cong Wu et al. Nutrients. .

Abstract

Sarcopenia has become a significant obstacle to healthy aging in older adults. Flavonoids may contribute to treating sarcopenia, and attenuate the age-related loss of skeletal muscle mass, muscle strength, and physical function, however, their benefits in sarcopenic individuals remain unclear. This systematic review aimed to evaluate the effect of flavonoids on muscle mass, muscle strength, and physical performance in adults with sarcopenia based on randomized controlled trials (RCTs). This review was conducted in conformity with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the risk of bias was assessed using the Cochrane risk of bias tool. The article search was conducted using PubMed, Scopus, Embase, Cochrane, Web of Science databases, and Google Scholar for the period until June 2023. RCTs that assessed the effects of flavonoids/flavonoids combined with other supplementation/flavonoid-rich supplementations on skeletal muscle mass, muscle strength, and physical performance in adults diagnosed with sarcopenia before intervention were included. From the 309 articles found, a total of 6 RCTs met the inclusion criteria. RCTs evaluated the main outcomes of tea catechins, epicatechin, and isoflavones intervention. Skeletal muscle mass significantly increased in three studies, muscle strength significantly elevated in two studies, and physical performance significantly improved in two studies. The majority of studies (five in six) found at least one of the main outcomes is elevated by flavonoids intervention. Flavonoids may have a great potential to treat sarcopenia.

Keywords: aging; flavonoids; nutrition; sarcopenia; skeletal muscle.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the selection process of the studies for systematic review.
Figure 2
Figure 2
Risk of bias for all included studies [26,27,28,29,30,31].
See this image and copyright information in PMC

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References

    1. Janssen I. Evolution of sarcopenia research. Appl. Physiol. Nutr. Metab. 2010;35:707–712. doi: 10.1139/H10-067. - DOI - PubMed
    1. Shaw S.C., Dennison E.M., Cooper C. Epidemiology of Sarcopenia: Determinants Throughout the Lifecourse. Calcif. Tissue Int. 2017;101:229–247. doi: 10.1007/s00223-017-0277-0. - DOI - PMC - PubMed
    1. Cruz-Jentoft A.J., Baeyens J.P., Bauer J.M., Boirie Y., Cederholm T., Landi F., Martin F.C., Michel J.P., Rolland Y., Schneider S.M., et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412–423. doi: 10.1093/ageing/afq034. - DOI - PMC - PubMed
    1. Marsh A.P., Rejeski W.J., Espeland M.A., Miller M.E., Church T.S., Fielding R.A., Gill T.M., Guralnik J.M., Newman A.B., Pahor M., et al. Muscle strength and BMI as predictors of major mobility disability in the Lifestyle Interventions and Independence for Elders pilot (LIFE-P) J. Gerontol. A Biol. Sci. Med. Sci. 2011;66:1376–1383. doi: 10.1093/gerona/glr158. - DOI - PMC - PubMed
    1. Ferri E., Marzetti E., Calvani R., Picca A., Cesari M., Arosio B. Role of Age-Related Mitochondrial Dysfunction in Sarcopenia. Int. J. Mol. Sci. 2020;21:5236. doi: 10.3390/ijms21155236. - DOI - PMC - PubMed

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