Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 31;13(8):776.
doi: 10.3390/bios13080776.

Recent Advances of Metal-Polyphenol Coordination Polymers for Biomedical Applications

Jing Qin  1 , Ningning Guo  1 , Jia Yang  1 , Yong Chen  1
Affiliations
Review

Recent Advances of Metal-Polyphenol Coordination Polymers for Biomedical Applications

Jing Qin et al. Biosensors (Basel). .

Abstract

Nanomedicine has provided cutting-edge technologies and innovative methods for modern biomedical research, offering unprecedented opportunities to tackle crucial biomedical issues. Nanomaterials with unique structures and properties can integrate multiple functions to achieve more precise diagnosis and treatment, making up for the shortcomings of traditional treatment methods. Among them, metal-polyphenol coordination polymers (MPCPs), composed of metal ions and phenolic ligands, are considered as ideal nanoplatforms for disease diagnosis and treatment. Recently, MPCPs have been extensively investigated in the field of biomedicine due to their facile synthesis, adjustable structures, and excellent biocompatibility, as well as pH-responsiveness. In this review, the classification of various MPCPs and their fabrication strategies are firstly summarized. Then, their significant achievements in the biomedical field such as biosensing, drug delivery, bioimaging, tumor therapy, and antibacterial applications are highlighted. Finally, the main limitations and outlooks regarding MPCPs are discussed.

Keywords: antibacterial; biomedical; metal–phenolic coordination polymers; polyphenol; tumor therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 3
Figure 3
(a) The synthesis of SmIII-EC nanoparticles self-assembly. Reprinted with permission from reference [21], 2019 Wiley. (b) The synthesis of MPCP colloidal spheres. (c) SEM image of Co-Fe-TA colloidal spheres. Reprinted with permission from reference [27], 2018 Wiley. (d) The synthesis of iron-polyphenol colloidal nanoparticles. Reprinted with permission from reference [29], 2021 Elsevier.
Figure 5
Figure 5
(a) Schematic illustrations of synthesized MPCP capsules using PS microspheres as templates. Reprinted with permission from reference [35], copyright 2014 Wiley. (b) Schematic illustrations of preparation of Fe-TA capsules using lignin as templates. Reprinted with permission from reference [36], copyright 2015 Wiley. (c) Schematic illustration of the fabrication process of DOX-loaded MPCP capsules and release mechanism of DOX from MPCP capsules. Reprinted with permission from reference [37], copyright 2018 Royal Society of Chemistry.
Figure 6
Figure 6
(a) Schematic illustrations of one-step and multistep assembly of Fe2+ and TA. Reprinted with permission from reference [41], 2013 American Association for the Advancement of Science. (b) Schematic illustrations of synthesized MPCP coating by spraying. Reprinted with permission from reference [43], 2018 American Chemical Society. (c) Schematic illustrations of MPCP coating prepared by electrochemical assembly. Reprinted with permission from reference [45], 2017 American Chemical Society.
Figure 12
Figure 12
(a) Schematic diagram of the GOx@ZIF@MPCP-nanoparticle-catalyzed Fenton reaction used to enhance CDT and hunger therapy for tumor ablation. Reprinted with permission from reference [91], copyright 2018 American Chemical Society. (b) Schematic of the proposed self-enhanced synergistic PTT/CDT/chemotherapy mechanism mediated by EFPD. Reprinted with permission from reference [81], copyright 2023 Wiley. (c) Schematic illustration of the constructed ssPPELap@Fe-TA for amplified ferroptosis-synergized immunotherapy. Reprinted with permission from reference [103], copyright 2023 American Chemical Society.
Figure 13
Figure 13
(a) Schematic illustration of the TNS-MPN-AMP nanocoating fabrication procedure [110]. Reprinted with permission from reference [110], copyright 2023 Elsevier. (b) Schematic illustration of the preparation process of ZIF-ICG@ZIF-GOx@MPN and its action mechanism for combined therapy to eradicate pathogenic bacteria. Reprinted with permission from reference [111], copyright 2023 American Chemical Society.
Figure 1
Figure 1
(a) The chemical structure of several plant polyphenols. (b–g) Covalent interactions and noncovalent interactions of plant polyphenols.
Figure 2
Figure 2
The review of various MPCPs structures for biomedical applications.
Figure 4
Figure 4
(a) Synthesis diagram and SEM image of Co-TA crystal particles. Reprinted with permission from reference [31], copyright 2016 Elsevier. (b) Schematic diagram of synthesis of Cu-TA crystals in the form of sea urchins. Reprinted with permission from reference [32], copyright 2018 Royal Society of Chemistry. (c) Schematic diagram of preparing mesoporous MPCP particles using the template method. Reprinted with permission from reference [34], copyright 2020 American Chemical Society.
Figure 7
Figure 7
(a) Schematic diagram of MPCP colloidal spheres based on fluorescent DNA detection. (b) Fluorescence recovery in different concentrations of miR-21. (c) Selectivity for the detection of miR-21. Reprinted with permission from reference [27], 2018 Wiley. (d) Schematic diagram of Cu-TA crystals based on fluorescent DNA detection. (e) Fluorescence spectra of the probe DNA under different conditions: (f) Selectivity for the detection of the DNA. Reprinted with permission from reference [32], 2018 Royal Society of Chemistry.
Figure 8
Figure 8
(a) Schematic illustrations of an MPCP capsules formed on a PS template particle. (b) Schematic illustrations of programming the permeability of MPCP capsules by endogenous and exogenous regulation of intermolecular dynamics. Reprinted with permission from reference [65] Copyright 2020 Wiley.
Figure 9
Figure 9
(a) Schematic diagram of preparation of Gd@PTCG NPs and MRI of tumors at different time. Reprinted with permission from reference [72], 2020 Wiley. (b) Schematic diagram of the preparation process of TA-Gd(III) and MRI of tumors with different concentration of TA-Gd(III). Reprinted with permission from reference [73], 2017 Wiley. (c) MRI of intratumor injection of Fe-CPNDs (tumor and arrow). Reprinted with permission from reference [24], 2015 Springer Nature.
Figure 10
Figure 10
(a) Pathways and mechanisms of SmIII-EC nanoparticles enucleated by tumor cells to induce mitochondrial apoptosis. Reprinted with permission from reference [21], 2019 Wiley. (b) Schematic diagram of the development of metastatic melanoma and mechanism of apoptosis induced by SmIII-EGCG nanocomplex. Reprinted with permission from reference [22], 2019 Elsevier. (c) Schematic illustration of HA@AQ4N-Cu(II)-gossypol for efficient synergistic chemotherapy. Reprinted with permission from reference [23], 2018 Elsevier.
Figure 11
Figure 11
(a,b) Template preparation of PNV@FeIII-TA and its PTT application for tumor therapy. Reprinted with permission from reference [84] 2018 American Chemical Society. (c) Schematic illustration of PTT applications of Fe-TA colloidal nanoparticles. Reprinted with permission from reference [29] 2021 Elsevier.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Wang H., Wang C.P., Zou Y., Hu J.J., Li Y.W., Cheng Y.Y. Natural polyphenols in drug delivery systems: Current status and future challenges. Giant. 2020;3:100022. doi: 10.1016/j.giant.2020.100022. - DOI
    1. Padmanabhan P., Kumar A., Kumar S., Chanudhary R.K., Gulyás B. Nanoparticles in Practice for molecular-imaging applications: An overview. Acta Biomater. 2016;41:1–16. doi: 10.1016/j.actbio.2016.06.003. - DOI - PubMed
    1. Li Y., Miao Y., Yang L.N., Zhao Y.T., Wu K.K., Lu Z.H., Hu Z.Q., Guo J.S. Recent advances in the development and antimicrobial applications of metal-phenolic networks. Adv. Sci. 2022;9:2202684. doi: 10.1002/advs.202202684. - DOI - PMC - PubMed
    1. Zhou Y., Zheng J., Li Y., Xu D.P., Li S., Chen Y.M., Li H.B. Natural polyphenols for prevention and treatment of cancer. Nutrients. 2016;8:515. doi: 10.3390/nu8080515. - DOI - PMC - PubMed
    1. Zhang X., Li Z., Yang P., Duan G.G., Liu X.H., Gu Z.P., Li Y.W. Polyphenol scaffolds in tissue engineering. Mater. Horiz. 2021;8:145–167. doi: 10.1039/D0MH01317J. - DOI - PubMed

Grants and funding

This research received no external funding.

LinkOut - more resources