Clinical application of COVID-19 vaccine in liver transplant recipients
- PMID: 37620225
- DOI: 10.1016/j.hbpd.2023.08.010
Clinical application of COVID-19 vaccine in liver transplant recipients
Abstract
Background: Solid organ transplant (SOT) activities, such as liver transplant, have been greatly influenced by the pandemic of coronavirus disease 2019 (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Immunosuppressed individuals of liver transplant recipients (LTRs) tend to have a high risk of COVID-19 infection and related complications. Therefore, COVID-19 vaccination has been recommended to be administered as early as possible in LTRs.
Data sources: The keywords "liver transplant", "SARS-CoV-2", and "vaccine" were used to retrieve articles published in PubMed.
Results: The antibody response following the 1st and 2nd doses of vaccination was disappointingly low, and the immune responses among LTRs remarkably improved after the 3rd or 4th dose of vaccination. Although the 3rd or 4th dose of COVID-19 vaccine increased the antibody titer, a proportion of patients remained unresponsive. Furthermore, recent studies showed that SARS-CoV-2 vaccine could trigger adverse events in LTRs, including allograft rejection and liver injury.
Conclusions: This review provides the recently reported data on the antibody response of LTRs following various doses of vaccine, risk factors for poor serological response and adverse events after vaccination.
Keywords: Antibody response; COVID-19; Liver transplant; SARS-CoV-2; Vaccine.
Copyright © 2023 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.
Conflict of interest statement
Competing interest No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Similar articles
-
Immune responses and clinical outcomes after COVID-19 vaccination in patients with liver disease and liver transplant recipients.J Hepatol. 2024 Jan;80(1):109-123. doi: 10.1016/j.jhep.2023.10.009. Epub 2023 Oct 19. J Hepatol. 2024. PMID: 37863203 Free PMC article.
-
Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases.J Hepatol. 2021 Dec;75(6):1434-1439. doi: 10.1016/j.jhep.2021.08.008. Epub 2021 Aug 26. J Hepatol. 2021. PMID: 34454993 Free PMC article.
-
Low immunogenicity to SARS-CoV-2 vaccination among liver transplant recipients.J Hepatol. 2021 Aug;75(2):435-438. doi: 10.1016/j.jhep.2021.04.020. Epub 2021 Apr 21. J Hepatol. 2021. PMID: 33892006 Free PMC article.
-
Coronavirus disease 2019 vaccination in transplant recipients.Curr Opin Infect Dis. 2021 Aug 1;34(4):275-287. doi: 10.1097/QCO.0000000000000739. Curr Opin Infect Dis. 2021. PMID: 34074880 Review.
-
The Immunology of SARS-CoV-2 Infection and Vaccines in Solid Organ Transplant Recipients.Viruses. 2021 Sep 20;13(9):1879. doi: 10.3390/v13091879. Viruses. 2021. PMID: 34578460 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous