Towards experimental models of delirium utilizing zebrafish

Gleb O Maslov¹, Konstantin N Zabegalov², Konstantin A Demin³, Tatiana O Kolesnikova⁴, Yuriy M Kositsyn⁵, Murilo S de Abreu⁶, Elena V Petersen⁷, Allan V Kalueff⁸

Affiliations

¹ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Ural Federal University, Ekaterinburg, Russia.
² National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
³ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁴ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁵ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁶ Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia. Electronic address: abreu_murilo@hotmail.com.
⁷ Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
⁸ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Novosibirsk State University, Novosibirsk, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

PMID: 37524203
DOI: 10.1016/j.bbr.2023.114607

Review

Towards experimental models of delirium utilizing zebrafish

Gleb O Maslov et al. Behav Brain Res. 2023.

. 2023 Sep 13:453:114607.

doi: 10.1016/j.bbr.2023.114607. Epub 2023 Jul 29.

Authors

Gleb O Maslov¹, Konstantin N Zabegalov², Konstantin A Demin³, Tatiana O Kolesnikova⁴, Yuriy M Kositsyn⁵, Murilo S de Abreu⁶, Elena V Petersen⁷, Allan V Kalueff⁸

Affiliations

¹ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Ural Federal University, Ekaterinburg, Russia.
² National Laboratory Astana, Nazarbayev University, Astana, Kazakhstan.
³ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁴ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁵ Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
⁶ Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia. Electronic address: abreu_murilo@hotmail.com.
⁷ Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
⁸ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Novosibirsk State University, Novosibirsk, Russia; Laboratory of Preclinical Bioscreening, Granov Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, Pesochny, Russia; Ural Federal University, Ekaterinburg, Russia. Electronic address: avkalueff@gmail.com.

PMID: 37524203
DOI: 10.1016/j.bbr.2023.114607

Abstract

Delirium is an acute neuropsychiatric condition characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.

Keywords: Delirium; Drug screening; Experimental models; Zebrafish.

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Towards experimental models of delirium utilizing zebrafish

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Towards experimental models of delirium utilizing zebrafish

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