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. 2023 Dec;19(12):1492-1503.
doi: 10.1038/s41589-023-01391-6. Epub 2023 Jul 27.

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism

Linchong Sun #  1 , Caixia Suo #  2 , Tong Zhang #  3 , Shengqi Shen #  3   4 , Xuemei Gu  5 , Shiqiao Qiu  5 , Pinggen Zhang  6 , Haoran Wei  3   4 , Wenhao Ma  6 , Ronghui Yan  6 , Rui Chen  5 , Weidong Jia  7 , Jie Cao  2 , Huafeng Zhang  8   9 , Ping Gao  10   11   12
Affiliations

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism

Linchong Sun et al. Nat Chem Biol. 2023 Dec.

Abstract

Enolase 1 (ENO1) is a glycolytic enzyme that plays essential roles in various pathological activities including cancer development. However, the mechanisms underlying ENO1-contributed tumorigenesis are not well explained. Here, we uncover that ENO1, as an RNA-binding protein, binds to the cytosine-uracil-guanine-rich elements of YAP1 messenger RNA to promote its translation. ENO1 and YAP1 positively regulate alternative arachidonic acid (AA) metabolism by inverse regulation of PLCB1 and HPGD (15-hydroxyprostaglandin dehydrogenase). The YAP1/PLCB1/HPGD axis-mediated activation of AA metabolism and subsequent accumulation of prostaglandin E2 (PGE2) are responsible for ENO1-mediated cancer progression, which can be retarded by aspirin. Finally, aberrant activation of ENO1/YAP1/PLCB1 and decreased HPGD expression in clinical hepatocellular carcinoma samples indicate a potential correlation between ENO1-regulated AA metabolism and cancer development. These findings underline a new function of ENO1 in regulating AA metabolism and tumorigenesis, suggesting a therapeutic potential for aspirin in patients with liver cancer with aberrant expression of ENO1 or YAP1.

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References

    1. Pavlova, N. N. & Thompson, C. B. The emerging hallmarks of cancer metabolism. Cell Metab. 23, 27–47 (2016). - PubMed - PMC - DOI
    1. Zhu, J. & Thompson, C. B. Metabolic regulation of cell growth and proliferation. Nat. Rev. Mol. Cell Biol. 20, 436–450 (2019). - PubMed - PMC - DOI
    1. Kim, J. W. & Dang, C. V. Multifaceted roles of glycolytic enzymes. Trends Biochem. Sci. 30, 142–150 (2005). - PubMed - DOI
    1. Yang, W. et al. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685–696 (2012). - PubMed - PMC - DOI
    1. Chang, C. H. et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153, 1239–1251 (2013). - PubMed - PMC - DOI

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