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. 2023 Dec;52(4):737-743.
doi: 10.1111/vcp.13286. Epub 2023 Jul 20.

Plasma chemistry reference intervals for adult multi-drug-resistance gene deficient Collies

M Joan Massat  1 , Matthew Myles  1 , Keith DeJong  1 , Chelsea Ballard  1 , Marlene Drag  1 , Thomas J Malinski  1
Affiliations

Plasma chemistry reference intervals for adult multi-drug-resistance gene deficient Collies

M Joan Massat et al. Vet Clin Pathol. 2023 Dec.

Abstract

Background: Differences in the reference intervals between dog breeds have been recognized for many years. Due to the importance of multi-drug-resistance 1-deficient (MDR1) Collies in veterinary medicine, it is important to determine whether breed-specific reference intervals are needed for this group.

Objectives: The goal of this study was to establish plasma chemistry reference intervals for adult MDR1-deficient Collies.

Methods: Plasma samples collected from 110 healthy male and female adult MDR1-deficient Collies were analyzed for 21 analytes on a Beckman AU480 clinical chemistry analyzer. Reference intervals were established using a nonparametric statistical method.

Results: Reference intervals were established for 21 biochemical measurands in healthy adult MDR1-deficient Collies.

Conclusion: Plasma chemistry reference intervals for MDR1-deficient Collies were clinically similar to intervals earlier created for Beagles. Intervals for male and female MDR1-deficient Collies were very similar to each other.

Keywords: canine; dog; normal; range.

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