NLRP3 inflammasome activation after ischemic stroke
- PMID: 37437697
- DOI: 10.1016/j.bbr.2023.114578
NLRP3 inflammasome activation after ischemic stroke
Abstract
Cerebral ischemia is a pathological condition resulting from the cessation or reduction of blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can arise as a result of brain damage. The etiology of stroke is multifaceted and intricate, with the inflammatory response being a crucial component that warrants significant attention. Following a cerebrovascular accident, the levels of interleukin-1 beta and interleukin-18 within the central nervous system escalate due to the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 inflammasome. The inflammation is aggravated by the subsequent occurrence of pyroptosis. The mechanisms that activate the NLRP3 inflammasome pyroptosis signaling pathway axis are described in this article. In addition, we go over how pyroptosis interacts with other processes for regulated cell death. In addition, specific NLRP3 inflammasome pathway inhibitors are identified, which offer new approaches to preventing ischemic brain injury.
Keywords: Inflammation; Ischemic stroke; NLRP3 inflammasome; NLRP3 inflammasome inhibitor; Pyroptosis.
Copyright © 2023 Elsevier B.V. All rights reserved.
Similar articles
-
Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke.J Neuroinflammation. 2021 May 31;18(1):123. doi: 10.1186/s12974-021-02137-8. J Neuroinflammation. 2021. PMID: 34059091 Free PMC article. Review.
-
Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.Mol Neurobiol. 2018 Feb;55(2):1082-1096. doi: 10.1007/s12035-017-0394-9. Epub 2017 Jan 14. Mol Neurobiol. 2018. PMID: 28092085
-
ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.J Transl Med. 2024 Jan 4;22(1):23. doi: 10.1186/s12967-023-04813-0. J Transl Med. 2024. PMID: 38178174 Free PMC article.
-
Janus Kinase Inhibition Ameliorates Ischemic Stroke Injury and Neuroinflammation Through Reducing NLRP3 Inflammasome Activation via JAK2/STAT3 Pathway Inhibition.Front Immunol. 2021 Jul 22;12:714943. doi: 10.3389/fimmu.2021.714943. eCollection 2021. Front Immunol. 2021. PMID: 34367186 Free PMC article.
-
NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes.J Neuroinflammation. 2019 Jun 7;16(1):121. doi: 10.1186/s12974-019-1498-0. J Neuroinflammation. 2019. PMID: 31174550 Free PMC article. Review.
Cited by
-
Detection of inflammasome activation in liver tissue during the donation process as potential biomarker for liver transplantation.Cell Death Discov. 2024 May 30;10(1):266. doi: 10.1038/s41420-024-02042-y. Cell Death Discov. 2024. PMID: 38816358 Free PMC article.
-
Accelerated Aging and the Life Course of Individuals Born Preterm.Children (Basel). 2023 Oct 13;10(10):1683. doi: 10.3390/children10101683. Children (Basel). 2023. PMID: 37892346 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
