Innovations in cell therapy in pediatric diseases: a narrative review
- PMID: 37427072
- PMCID: PMC10326759
- DOI: 10.21037/tp-23-92
Innovations in cell therapy in pediatric diseases: a narrative review
Abstract
Background and objective: Stem cell therapy is a regenerative medicine modality that has the potential to decrease morbidity and mortality by promoting tissue regeneration or modulating the inflammatory response. An increase in the number of clinical trials investigating the efficacy and safety of stem cell therapy in pediatric diseases has led to advancements in this field. Currently, multiple sources and types of stem cells have been utilized in the treatment of pediatric diseases. This review aims to inform researchers and clinicians about preclinical and clinical stem cell therapy trials in pediatric patients. We discuss the different types of stem cells and the wide spectrum of stem cell therapy trials for pediatric diseases, with an emphasis on the outcomes and advancements in the field.
Methods: PubMed and clinicaltrials.gov databases were searched on October 28, 2022 using the following Medical Subject Headings (MeSH) terms "stem cell" or "stem cell therapy" with an age filter <18 years. Our search was limited to publications published between 2000 and 2022.
Key content and findings: Diverse sources of stem cells have different properties and mechanisms of action, which allow tailored application of stem cells according to the pathophysiology of the disease. Advancements in stem cell therapies for pediatric diseases have led to improvements in clinical outcomes in some pediatric diseases or in quality of life, such therapies represent a potential alternative to the current treatment modalities.
Conclusions: Stem cell therapy in pediatric diseases has shown promising results and outcomes. However, further studies focusing on the implementation and optimal treatment timeframe are needed. An increase in preclinical and clinical trials of stem cell therapy targeting pediatric patients is required to advance our therapeutic applications.
Keywords: Cell therapy; innovations; pediatric diseases; stem cell.
2023 Translational Pediatrics. All rights reserved.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-23-92/coif). The series “The Impact of the Progresses of Knowledge and Technologies in Pediatrics” was commissioned by the editorial office without any funding or sponsorship. RES received support for attending meetings and/or travel from University of Texas. CSC reports grants/contracts received from NIH, DOD/MTEC/CDMRP, HopeBio, and Athersys, royalties or licenses from EMIT, Coagulex, and Cellvation, consulting fees from Stream Biomedical, payments or honoraria from CellCare Australia, and Generate Life Sciences, and support for attending meetings and/or travel from CTTACC. CSC has patents planned, issued or pending by University of Texas, participates on advisory board for Duke University, and holds stock or stock options from Cellvation, Inc. The authors have no other conflicts of interests to declare.
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