Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019
- PMID: 37302558
- DOI: 10.1053/j.gastro.2023.05.050
Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019
Abstract
Background & aims: This study assessed the worldwide burden of digestive diseases between 1990 and 2019.
Methods: We analyzed data from the Global Burden of Diseases study, covering 18 digestive diseases across 204 countries and territories. Key disease burden indicators, including incidence, prevalence, mortality, and disability-adjusted life years (DALYs), were studied. Linear regression analysis was applied to the natural logarithm of age-standardized outcomes to determine the annual percent change.
Results: In 2019, there were 7.32 billion incidents and 2.86 billion prevalent cases of digestive diseases, resulting in 8 million deaths and 277 million DALYs lost. Little to no decrease in global age-standardized incidence and prevalence of digestive diseases was observed between 1990 and 2019, with 95,582 and 35,106 cases per 100,000 individuals in 2019, respectively. The age-standardized death rate was 102 per 100,000 individuals. Digestive diseases accounted for a significant portion of the overall disease burden, with more than one-third of prevalent cases having a digestive etiology. Enteric infections were the primary contributor to incidence, death, and DALYs lost, whereas cirrhosis and other chronic liver diseases had the highest prevalence rate. The burden of digestive diseases was inversely related to the sociodemographic index, with enteric infections being the predominant cause of death in low and low-middle quintiles and colorectal cancer in the high quintile.
Conclusions: Despite significant reductions in deaths and DALYs due to digestive diseases from 1990 to 2019, they remain prevalent. A significant disparity in the burden of digestive diseases exists among countries with different development levels.
Keywords: Digestive Disease; Disparity; Epidemiology; Gastrointestinal Disease; Global Burden.
Copyright © 2023 AGA Institute. Published by Elsevier Inc. All rights reserved.
Comment in
-
Global Inequalities in the Burden of Digestive Diseases From 1990 to 2019: Findings From the Global Burden of Disease Study 2019.Gastroenterology. 2024 Jan;166(1):223-224.e1. doi: 10.1053/j.gastro.2023.09.024. Epub 2023 Sep 20. Gastroenterology. 2024. PMID: 37734421 No abstract available.
Similar articles
-
Global, regional, and national burden of 10 digestive diseases in 204 countries and territories from 1990 to 2019.Front Public Health. 2023 Mar 28;11:1061453. doi: 10.3389/fpubh.2023.1061453. eCollection 2023. Front Public Health. 2023. PMID: 37056655 Free PMC article.
-
The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.Lancet Gastroenterol Hepatol. 2020 Mar;5(3):245-266. doi: 10.1016/S2468-1253(19)30349-8. Epub 2020 Jan 22. Lancet Gastroenterol Hepatol. 2020. PMID: 31981519 Free PMC article.
-
Epidemiology and Socioeconomic Impact of Pancreatic Cancer: An Analysis of the Global Burden of Disease Study 1990-2019.Dig Dis Sci. 2024 Apr;69(4):1135-1142. doi: 10.1007/s10620-024-08292-1. Epub 2024 Feb 21. Dig Dis Sci. 2024. PMID: 38383939
-
Global burden and risk factors of musculoskeletal disorders among adolescents and young adults in 204 countries and territories, 1990-2019.Autoimmun Rev. 2023 Aug;22(8):103361. doi: 10.1016/j.autrev.2023.103361. Epub 2023 May 23. Autoimmun Rev. 2023. PMID: 37230312 Review.
-
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study.J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. doi: 10.1016/j.jacc.2020.11.010. J Am Coll Cardiol. 2020. PMID: 33309175 Free PMC article. Review.
Cited by
-
Comparison of the burden of digestive diseases between China and the United States from 1990 to 2019.Front Public Health. 2024 May 17;12:1376406. doi: 10.3389/fpubh.2024.1376406. eCollection 2024. Front Public Health. 2024. PMID: 38827620 Free PMC article.
-
Can diet change the natural history of gastrointestinal diseases?JGH Open. 2024 May 20;8(5):e13063. doi: 10.1002/jgh3.13063. eCollection 2024 May. JGH Open. 2024. PMID: 38770354 Free PMC article. Review.
-
Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds.Open Life Sci. 2024 Apr 18;19(1):20220857. doi: 10.1515/biol-2022-0857. eCollection 2024. Open Life Sci. 2024. PMID: 38645751 Free PMC article. Review.
-
IL-22-dependent responses and their role during Citrobacter rodentium infection.Infect Immun. 2024 May 7;92(5):e0009924. doi: 10.1128/iai.00099-24. Epub 2024 Apr 1. Infect Immun. 2024. PMID: 38557196 Free PMC article.
-
NMR and MS reveal characteristic metabolome atlas and optimize esophageal squamous cell carcinoma early detection.Nat Commun. 2024 Mar 19;15(1):2463. doi: 10.1038/s41467-024-46837-0. Nat Commun. 2024. PMID: 38504100 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources