Sleep mediates the effect of stressful environments on youth development of impulsivity: The moderating role of within default mode network resting-state functional connectivity
- PMID: 37270396
- PMCID: PMC10524131
- DOI: 10.1016/j.sleh.2023.03.005
Sleep mediates the effect of stressful environments on youth development of impulsivity: The moderating role of within default mode network resting-state functional connectivity
Abstract
Objectives: Youth raised in stressful environments are at increased risk for developing impulsive traits, which are a robust precursor of problem behaviors. Sleep may mediate the link between stress and problem behaviors as it is both sensitive to stress and essential for neurocognitive development underlying behavioral control during adolescence. The default mode network (DMN) is a brain network implicated in stress regulation and sleep. Yet, it is poorly understood how individual differences in resting-state DMN moderate the effect of stressful environments on impulsivity via sleep problems.
Methods: Three waves of data spanning 2 years were obtained from the Adolescent Brain and Cognitive Development Study, a national longitudinal sample of 11,878 children (Mage at baseline = 10.1; 47.8% female). Structural equation modeling was used to test (a) the mediating role of sleep at T3 in the link between stressful environments at baseline and impulsivity at T5 and (b) the moderation of this indirect association by baseline levels of within-DMN resting-state functional connectivity.
Results: Sleep problems, shorter sleep duration, and longer sleep latency significantly mediated the link between stressful environments and youth impulsivity. Youth with elevated within-DMN resting-state functional connectivity showed intensified associations between stressful environments and impulsivity via shorter sleep duration.
Conclusion: Our findings suggest that sleep health can be a target for preventive intervention and thereby mitigate the link between stressful environments and increased levels of youth impulsivity.
Keywords: Default mode network; Resting-state functional connectivity; Sleep duration; Sleep latency; Stressful environments; fMRI.
Copyright © 2023 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of conflict of interest The authors have declared no conflicts of interest.
Similar articles
-
Getting a Good Night's Sleep: Associations Between Sleep Duration and Parent-Reported Sleep Quality on Default Mode Network Connectivity in Youth.J Adolesc Health. 2023 Jun;72(6):933-942. doi: 10.1016/j.jadohealth.2023.01.010. Epub 2023 Mar 3. J Adolesc Health. 2023. PMID: 36872118 Free PMC article.
-
The mediating role of default mode network during meaning-making aroused by mental simulation between stressful events and stress-related growth: a task fMRI study.Behav Brain Funct. 2023 Jul 15;19(1):12. doi: 10.1186/s12993-023-00214-x. Behav Brain Funct. 2023. PMID: 37454095 Free PMC article.
-
Sleep quality and adolescent default mode network connectivity.Soc Cogn Affect Neurosci. 2018 Mar 1;13(3):290-299. doi: 10.1093/scan/nsy009. Soc Cogn Affect Neurosci. 2018. PMID: 29432569 Free PMC article.
-
Neural connectivity moderates the association between sleep and impulsivity in adolescents.Dev Cogn Neurosci. 2017 Oct;27:35-44. doi: 10.1016/j.dcn.2017.07.006. Epub 2017 Jul 26. Dev Cogn Neurosci. 2017. PMID: 28777996 Free PMC article.
-
Model-free functional connectivity and impulsivity correlates of alcohol dependence: a resting-state study.Addict Biol. 2017 Jan;22(1):206-217. doi: 10.1111/adb.12272. Epub 2015 Jun 3. Addict Biol. 2017. PMID: 26040546 Free PMC article.
References
-
- Smith KE, Pollak SD. Early life stress and development: potential mechanisms for adverse outcomes. Journal of Neurodevelopmental Disorders. 2020;12:1–15. doi.org/10.1186/s11689-020-09337-y. - DOI - PMC - PubMed
-
- Oshri A, Kogan S, Liu S, Sweet L, Mackillop J. Pathways linking adverse childhood experiences to cigarette smoking among young black men: A prospective analysis of the role of sleep problems and delayed reward discounting. Annals of Behavioral Medicine. 2017;51(6):890–898. doi.org/10.1007/s12160-017-9914-0. - DOI - PMC - PubMed
-
- Demos K, Hart C, Sweet L, et al. Partial sleep deprivation impacts impulsive action but not impulsive decision-making. Physiology & Behavior. 2016;164:214–219. doi.org/10.1016/j.physbeh.2016.06.003. - DOI - PMC - PubMed
-
- Tashjian SM, Goldenberg D, Galván A. Neural connectivity moderates the association between sleep and impulsivity in adolescents. Developmental Cognitive Neuroscience. 2017;27:35–44. doi.org/10.1016/j.dcn.2017.07.006. - DOI - PMC - PubMed
-
- Zhu X, Cortes CR, Mathur K, Tomasi D, Momenan R. Model-free functional connectivity and impulsivity correlates of alcohol dependence: a resting-state study. Addiction Biology. 2017;22(1):206–217. doi.org/10.1111/adb.12272. - DOI - PMC - PubMed
Publication types
MeSH terms
Grants and funding
- U24 DA041147/DA/NIDA NIH HHS/United States
- U01 DA051039/DA/NIDA NIH HHS/United States
- U01 DA041120/DA/NIDA NIH HHS/United States
- U01 DA051018/DA/NIDA NIH HHS/United States
- U01 DA041093/DA/NIDA NIH HHS/United States
- U01 DA051038/DA/NIDA NIH HHS/United States
- U01 DA041134/DA/NIDA NIH HHS/United States
- P50 DA051361/DA/NIDA NIH HHS/United States
- U01 DA051037/DA/NIDA NIH HHS/United States
- U01 DA051016/DA/NIDA NIH HHS/United States
- U01 DA050989/DA/NIDA NIH HHS/United States
- U01 DA041117/DA/NIDA NIH HHS/United States
- U01 DA041148/DA/NIDA NIH HHS/United States
- U01 DA041174/DA/NIDA NIH HHS/United States
- U24 DA041123/DA/NIDA NIH HHS/United States
- R01 DA058334/DA/NIDA NIH HHS/United States
- U01 DA041156/DA/NIDA NIH HHS/United States
- U01 DA050987/DA/NIDA NIH HHS/United States
- U01 DA041089/DA/NIDA NIH HHS/United States
- U01 DA050988/DA/NIDA NIH HHS/United States
- U01 DA041106/DA/NIDA NIH HHS/United States
- K01 DA045219/DA/NIDA NIH HHS/United States
- U01 DA041028/DA/NIDA NIH HHS/United States
- U01 DA041048/DA/NIDA NIH HHS/United States
LinkOut - more resources
Full Text Sources
Medical