Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle
- PMID: 3726555
- DOI: 10.1126/science.3726555
Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle
Abstract
Human circadian rhythms were once thought to be insensitive to light, with synchronization to the 24-hour day accomplished either through social contacts or the sleep-wake schedule. Yet the demonstration of an intensity-dependent neuroendocrine response to bright light has led to renewed consideration of light as a possible synchronizer of the human circadian pacemaker. In a laboratory study, the output of the circadian pacemaker of an elderly woman was monitored before and after exposure to 4 hours of bright light for seven consecutive evenings, and before and after a control study in ordinary room light while her sleep-wake schedule and social contacts remained unchanged. The exposure to bright light in the evening induced a 6-hour delay shift of her circadian pacemaker, as indicated by recordings of body temperature and cortisol secretion. The unexpected magnitude, rapidity, and stability of the shift challenge existing concepts regarding circadian phase-resetting capacity in man and suggest that exposure to bright light can indeed reset the human circadian pacemaker, which controls daily variations in physiologic, behavioral, and cognitive function.
Similar articles
-
Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure.J Physiol. 1996 Aug 15;495 ( Pt 1)(Pt 1):289-97. doi: 10.1113/jphysiol.1996.sp021593. J Physiol. 1996. PMID: 8866371 Free PMC article.
-
Melatonin rhythm observed throughout a three-cycle bright-light stimulus designed to reset the human circadian pacemaker.J Biol Rhythms. 1999 Jun;14(3):237-53. doi: 10.1177/074873099129000560. J Biol Rhythms. 1999. PMID: 10452336
-
Differential regulation of circadian melatonin rhythm and sleep-wake cycle by bright lights and nonphotic time cues in humans.Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R546-57. doi: 10.1152/ajpregu.00087.2014. Epub 2014 Jun 18. Am J Physiol Regul Integr Comp Physiol. 2014. PMID: 24944250
-
Light treatment for sleep disorders: consensus report. II. Basic properties of circadian physiology and sleep regulation.J Biol Rhythms. 1995 Jun;10(2):113-25. doi: 10.1177/074873049501000204. J Biol Rhythms. 1995. PMID: 7632985 Review.
-
Circadian and sleep-dependent regulation of hormone release in humans.Recent Prog Horm Res. 1999;54:97-130; discussion 130-2. Recent Prog Horm Res. 1999. PMID: 10548874 Review.
Cited by
-
A perspective on the Festschrift of Charles A. Czeisler, PhD MD.Sleep Health. 2024 Feb;10(1S):S4-S10. doi: 10.1016/j.sleh.2024.01.003. Epub 2024 Feb 7. Sleep Health. 2024. PMID: 38331654 No abstract available.
-
Effects of chronotype-tailored bright light intervention on post-treatment symptoms and quality of life in breast cancer survivors.Support Care Cancer. 2023 Nov 17;31(12):705. doi: 10.1007/s00520-023-08157-9. Support Care Cancer. 2023. PMID: 37975923 Clinical Trial.
-
Association Between Vision-Related Functional Burden and Sleep Disorders in Adults Aged 20 and Over in the United States.Transl Vis Sci Technol. 2023 Nov 1;12(11):3. doi: 10.1167/tvst.12.11.3. Transl Vis Sci Technol. 2023. PMID: 37917088 Free PMC article.
-
Translation and Validation of the Arabic Version of the Athlete Sleep Screening Questionnaire.Healthcare (Basel). 2023 May 22;11(10):1501. doi: 10.3390/healthcare11101501. Healthcare (Basel). 2023. PMID: 37239787 Free PMC article.
-
Latent profile analysis of post-traumatic stress and post-traumatic growth among firefighters.Eur J Psychotraumatol. 2023;14(1):2159048. doi: 10.1080/20008066.2022.2159048. Eur J Psychotraumatol. 2023. PMID: 37052101 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources