Retrospective evaluation of the efficacy of daily paroxetine/tadalafil combination in patients with premature ejaculation and erectile dysfunction
- PMID: 37203851
- DOI: 10.26355/eurrev_202305_32335
Retrospective evaluation of the efficacy of daily paroxetine/tadalafil combination in patients with premature ejaculation and erectile dysfunction
Abstract
Objective: Premature ejaculation (PE) and erectile dysfunction (ED) are sexual dysfunction diseases affecting males. The phosphodiesterase type 5 (PDE5) inhibitors such as tadalafil are used to treat ED whereas selective serotonin reuptake inhibitors (SSRIs) are preferred for PE. Most of the patients with ED also suffer from PE simultaneously. The combined drug therapies are commonly preferred as they favor elevated intra-vaginal ejaculation latency time (IELT) scores and improved sexual function. The study aimed to evaluate the efficacy and safety of daily paroxetine and tadalafil combination therapy in patients with PE and ED.
Patients and methods: A total of 81 PE patients with ED were enrolled in the study. Patients were treated with daily paroxetine 20 mg and tadalafil 5 mg for 4 weeks. Pre- and post-treatment IELT, premature ejaculation profile (PEP), and International Index of Erectile Function-Erectile Function (IIEF-EF) scores of the patients were analyzed.
Results: The mean IELT and PEP index scores, and mean IIEF-EF values improved after combination therapy (p<0.001 for each). When lifelong and acquired PE+ED patients were compared, significant improvements were observed in IELT, PEP, and IIEF-EF scores in both groups (p<0.001).
Conclusions: Even though the treatment methods are different, combined therapies to treat simultaneous PE and ED presence are effective compared to monotherapies. However, there is still no definitive treatment that can cure all subtypes of PE or ED.
Similar articles
-
Combination therapy with selective serotonin reuptake inhibitors and phosphodiesterase-5 inhibitors in the treatment of premature ejaculation.Andrologia. 2015 Jun;47(5):487-92. doi: 10.1111/and.12289. Epub 2014 May 9. Andrologia. 2015. PMID: 24811578 Clinical Trial.
-
Efficacy and safety of dapoxetine/sildenafil combination tablets in the treatment of men with premature ejaculation and concomitant erectile dysfunction-DAP-SPEED Study.Int J Impot Res. 2019 Mar;31(2):92-96. doi: 10.1038/s41443-019-0122-2. Epub 2019 Jan 31. Int J Impot Res. 2019. PMID: 30705437 Clinical Trial.
-
Efficacy and safety of dapoxetine in men with premature ejaculation and concomitant erectile dysfunction treated with a phosphodiesterase type 5 inhibitor: randomized, placebo-controlled, phase III study.J Sex Med. 2013 Sep;10(9):2312-25. doi: 10.1111/jsm.12236. Epub 2013 Jul 11. J Sex Med. 2013. PMID: 23845016 Clinical Trial.
-
Interventions to treat premature ejaculation: a systematic review short report.Health Technol Assess. 2015 Mar;19(21):1-180, v-vi. doi: 10.3310/hta19210. Health Technol Assess. 2015. PMID: 25768099 Free PMC article. Review.
-
[Research progress of combination therapy in the treatment of erectile dysfunction and premature ejaculation comorbidity].Zhonghua Nan Ke Xue. 2023 Sep;29(9):771-775. Zhonghua Nan Ke Xue. 2023. PMID: 38639587 Review. Chinese.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous