Changes in concentrations of melatonin, PlGF, and cytokines in women with preeclampsia
- PMID: 37168313
- PMCID: PMC10165510
- DOI: 10.25122/jml-2022-0283
Changes in concentrations of melatonin, PlGF, and cytokines in women with preeclampsia
Abstract
Preeclampsia (PE) is a pregnancy-related disorder that significantly increases the risk of maternal and fetal morbidity and mortality. Melatonin, a potent antioxidant, has been suggested to mitigate oxidative stress and associated damage in various pathological conditions. Placental growth factor (PlGF) plays a vital role in placental development by promoting angiogenesis. This study aimed to investigate whether the levels of melatonin, cytokines, and PlGF were higher in the venous blood of women with preeclampsia during the third trimester of pregnancy compared to those with uncomplicated pregnancies. The study involved 32 women with preeclampsia and 33 healthy pregnant women as a control group. The concentrations of melatonin and PlGF were significantly lower in women with preeclampsia compared to healthy pregnant women. Specifically, the mean level of melatonin in the preeclampsia group was 30.98 pg/ml and 55.20 pg/ml in the control group (p=0.029). Similarly, the mean level of PlGF in the preeclampsia group was 40.03 pg/ml and 213.31 pg/ml in the control group (p<0.0001). This suggests that alterations in the placental production of melatonin and PlGF may contribute to the development of preeclampsia. In contrast, we observed higher levels of the pro-inflammatory cytokine interleukin-6 (IL-6) and the anti-inflammatory cytokine interleukin-10 (IL-10) in the preeclampsia group than in the control group. The mean concentration of IL-6 in the PE group was 270.79 pg/ml, whereas the control group had 224.30 pg/ml (p=0.022). Similarly, the mean concentration of IL-10 in the PE group was 41.90 pg/ml and 30.73 pg/ml in the control group (p=0.018). In women with uncomplicated pregnancies, the interaction between pro-inflammatory interleukine-6 and melatonin can be described by equality of statistical regression.
Keywords: CNS – central nervous system; FLT-1 – Fms-related tyrosine kinase-1; IL – interleukin; PE – preeclampsia; PlGF – placental growth factor; cytokines; melatonin; placental growth factor; preeclampsia; pregnancy.
©2023 JOURNAL of MEDICINE and LIFE.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
-
Association between Placental Lesions, Cytokines and Angiogenic Factors in Pregnant Women with Preeclampsia.PLoS One. 2016 Jun 17;11(6):e0157584. doi: 10.1371/journal.pone.0157584. eCollection 2016. PLoS One. 2016. PMID: 27315098 Free PMC article.
-
Melatonin Levels Decrease in the Umbilical Cord in Case of Intrauterine Growth Restriction.J Med Life. 2020 Oct-Dec;13(4):548-553. doi: 10.25122/jml-2020-0128. J Med Life. 2020. PMID: 33456605 Free PMC article.
-
Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?Am J Obstet Gynecol. 2008 Apr;198(4):428.e1-6. doi: 10.1016/j.ajog.2007.10.783. Epub 2008 Jan 14. Am J Obstet Gynecol. 2008. PMID: 18191808
-
Combining Biomarkers to Predict Pregnancy Complications and Redefine Preeclampsia: The Angiogenic-Placental Syndrome.Hypertension. 2020 Apr;75(4):918-926. doi: 10.1161/HYPERTENSIONAHA.119.13763. Epub 2020 Feb 17. Hypertension. 2020. PMID: 32063058 Free PMC article. Review.
-
The Use of Soluble FMS-like Tyrosine Kinase 1/Placental Growth Factor Ratio in the Clinical Management of Pre-eclampsia.Afr J Reprod Health. 2018 Dec;22(4):135-143. doi: 10.29063/ajrh2018/v22i1.14. Afr J Reprod Health. 2018. PMID: 30632730 Review.
Cited by
-
Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences.Int J Mol Sci. 2024 Mar 24;25(7):3632. doi: 10.3390/ijms25073632. Int J Mol Sci. 2024. PMID: 38612445 Free PMC article. Review.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous