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. 2023 Apr 19;8(17):15152-15159.
doi: 10.1021/acsomega.3c00148. eCollection 2023 May 2.

Progeny Transfer Effects of Chitosan-Coated Cobalt Ferrite Nanoparticles

Md Salman Shakil  1 , Md Forhad Uddin  2 , Md Reaz Morshed  3 , Md Simul Bhuiya  2 , Morshed Alam  2 , Md Sakib Hossen  4 , Mahruba Sultana Niloy  2 , Mohammad Mahfuz Ali Khan Shawan  2 , Sheikh Manjura Hoque  5 , Md Ashraful Hasan  2
Affiliations

Progeny Transfer Effects of Chitosan-Coated Cobalt Ferrite Nanoparticles

Md Salman Shakil et al. ACS Omega. .

Abstract

Cobalt ferrite nanoparticles (CFNs) are promising materials for their enticing properties for different biomedical applications, including magnetic resonance imaging (MRI) contrast, drug carriers, biosensors, and many more. In our previous study, a chitosan-coated CFN (CCN) nanocomplex demonstrated potential as an MRI contrast dye by improving the biocompatibility of CFN. In this study, we report the progeny transfer effects of CCN following a single intravenous injection of CCN (20, 40, or 60 mg/kg) in pregnant albino Wistar rats. Biochemical and histological observation reveals that CCN is tolerated with respect to maternal organ functions (e.g., liver, kidney). Atomic absorption spectroscopy results showed that CCN or CCN-leached iron could cross the placental barrier and deposit in the fetus. Furthermore, this deposition accelerated lipid peroxidation in the placenta and fetus.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Histological images of the (a) liver, (b) kidney, (c) placenta, and (d) fetus. Sections of the (a) liver, (b) kidney, (c) placenta, and (d) fetus tissues were collected from the pregnant albino Wistar rats following 24 and 48 h of CCNs (20–60 mg/kg) postinjection. On the other hand, the CN group received an intravenous injection of PBS. Tissue samples were prepared with hematoxylin and eosin (H&E) stains. Any sign of tissue damage was not observed in the case compared to the control. Images were taken at 400×. CN, control; CCN, chitosan-coated cobalt ferrite nanoparticles.
Figure 2
Figure 2
Time- and concentration-dependent effects of CCNs on biochemical parameters. Pregnant albino Wistar rats were sacrificed following 24 and 48 h of CCN (20–60 mg/kg) postinjection. ALT (a), AST (b), ALP (c), albumin (d), creatinine (e), BUN (f), uric acid (g), BUN/creatinine ratio (h), sodium (i), and potassium (j) concentration were calculated to detect the effect of CCNs on these biochemical parameters. Values are presented as mean ± SEM, three animals per group. Two-way ANOVA coupled with a Tukey’s posthoc test was used to analyze experimental data. *p > 0.05, significantly different compared to control. CCN, chitosan-coated cobalt ferrite nanoparticles.
Figure 3
Figure 3
Time- and concentration-dependent clearance of iron from the liver, placenta, and fetus. Pregnant albino Wistar rats were sacrificed following 24 and 48 h of CCN (20–60 mg/kg) postinjection. AAS analysis was performed to detect the iron level in the liver (a), placenta (b), and fetus (c). Values are presented as mean ± SEM, three animals per group. Two-way ANOVA coupled with a Tukey’s posthoc test was used to analyze experimental data. *p > 0.05, significantly different compared to control. AAS, atomic absorption spectroscopy; CCN, chitosan-coated cobalt ferrite nanoparticles.
Figure 4
Figure 4
Time- and concentration-dependent lipid peroxidation of the liver, fetus, and placenta. Pregnant albino Wistar rats were sacrificed following 24 and 48 h of CCN (20–60 mg/kg) postinjection. LPO analysis was performed to detect the oxidative stress in the liver (a), fetus (b), and placenta (c). Values are presented as mean ± SEM, three animals per group. Two-way ANOVA coupled with a Tukey’s posthoc test was used to analyze experimental data. *p > 0.05, significantly different compared to control. CCN, chitosan-coated cobalt ferrite nanoparticles.
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