Effect of house dust mite allergen on sleep parameters and sleep quality
- PMID: 37093511
- DOI: 10.1007/s11325-023-02832-1
Effect of house dust mite allergen on sleep parameters and sleep quality
Abstract
Purpose: The role of nasal problems such as allergic rhinitis in the development of obstructive sleep apnea (OSA) is controversial. The purpose of this study was to analyze the effects of house dust mite (HDM) allergen on sleep-related problems.
Methods: In a retrospective study patients were classified according to the house dust mite (HDM)-related specific immunoglobulin E (IgE) level into a low HDM-IgE group (group A) and a high HDM-IgE group (group B). Polysomnographic indices, OSA severity, and self-administered questionnaire results were compared between groups. Correlational analysis was used to identify associations between specific IgE values and sleep parameters related to respiratory events.
Results: A total of 327 patients were enrolled. N1 stage ratio, apnea index, and apnea-hypopnea index were significantly higher in group B (P = 0.010, 0.003, and 0.002 respectively) than in group A. N2 stage ratio, and lowest and mean oxygen saturation were significantly lower in group B (P = 0.001, 0.001, and < 0.001 respectively). After propensity score matching, the apnea index and lowest and mean oxygen saturation remained significantly different (P = 0.005, 0.005, and 0.001 respectively). Patients in group B were more likely to have severe OSA and worse subjective sleep quality. In correlational analysis, lowest and mean oxygen saturation were significantly negatively correlated with specific IgE values.
Conclusion: A high HDM-specific IgE level was associated with the occurrence of respiratory events and oxygen desaturation during sleep, and with the presence of severe OSA, as well as poorer subjective sleep quality.
Keywords: Allergic rhinitis; House dust mite; Obstructive sleep apnea.
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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References
-
- Abbasi A, Gupta SS, Sabharwal N et al (2021) A comprehensive review of obstructive sleep apnea. Sleep Sci 14:142–154. https://doi.org/10.5935/1984-0063.20200056 - DOI - PubMed - PMC
-
- American Academy of Sleep Medicine (2014) International Classification of Sleep Disorders, 3rd edn. American Academy of Sleep Medicine, Darien, IL
-
- Gottlieb DJ, Punjabi NM (2020) Diagnosis and management of obstructive sleep apnea: a review. JAMA 323:1389–1400. https://doi.org/10.1001/jama.2020.3514 - DOI - PubMed
-
- Patil SP, Ayappa IA, Caples SM et al (2019) Treatment of adult obstructive sleep apnea with positive airway pressure: an American academy of sleep medicine clinical practice guideline. J Clin Sleep Med 15:335–343. https://doi.org/10.5664/jcsm.7640 - DOI - PubMed - PMC
-
- Carneiro-Barrera A, Díaz-Román A, Guillén-Riquelme A, Buela-Casal G (2019) Weight loss and lifestyle interventions for obstructive sleep apnoea in adults: systematic review and meta-analysis. Obes Rev 20:750–762. https://doi.org/10.1111/obr.12824 - DOI - PubMed
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