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. 2023 Sep;60(9):e14311.
doi: 10.1111/psyp.14311. Epub 2023 Apr 19.

Family study of the startle reflex and event-related potentials in anticipation of predictable and unpredictable threat in adolescents and their parents

Rachel A Ferry  1 , Clare C Beatty  1 , Daniel N Klein  1 , Brady D Nelson  1
Affiliations

Family study of the startle reflex and event-related potentials in anticipation of predictable and unpredictable threat in adolescents and their parents

Rachel A Ferry et al. Psychophysiology. 2023 Sep.

Abstract

A heightened sensitivity to unpredictable threat has been identified as a potential transdiagnostic mechanism of psychopathology. The majority of supporting research has been conducted in adults, and it is unclear whether psychophysiological indicators of sensitivity to unpredictable threat are comparable in youth during developmental periods associated with increased risk for psychopathology. In addition, no studies have examined whether sensitivity to unpredictable threat is correlated between parents and their offspring. The present study examined defensive motivation (startle reflex) and attentional engagement (probe N100, P300) in anticipation of predictable and unpredictable threat in a sample of 15-year-old adolescents (N = 395) and a biological parent (N = 379). Adolescents, compared to their parents, demonstrated greater startle potentiation and probe N100 enhancement in anticipation of unpredictable threat. In addition, overall startle potentiation in anticipation of threat was correlated between the adolescents and their parents. Adolescence is a key developmental period characterized by heightened defensive motivation and attentional engagement in anticipation of both predictable and unpredictable threat. Sensitivity to threat might index is one mechanism of vulnerability that is at least partially shared between parents and their offspring.

Keywords: event-related potentials; startle reflex; threat; unpredictability.

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Conflict of interest statement

Conflict of Interest

The authors declare that they have no conflict of interest

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References

    1. Ahmadzadeh YI, Eley TC, Leve LD, Shaw DS, Natsuaki MN, Reiss D, Neiderhiser JM, & McAdams TA (2019). Anxiety in the family: a genetically informed analysis of transactional associations between mother, father and child anxiety symptoms. Journal of Child Psychology and Psychiatry and Allied Disciplines, 60(12), 1269–1277. 10.1111/jcpp.13068 - DOI - PMC - PubMed
    1. Anokhin AP, Golosheykin S, & Heath AC (2010). Heritability of individual differences in cortical processing of facial affect. Behavior Genetics, 40(2), 178–185. 10.1007/s10519-010-9337-1 - DOI - PMC - PubMed
    1. Blumenthal TD, Cuthbert BN, Filion DL, Hackley S, Lipp O. v., & van Boxtel A (2005). Committee report: Guidelines for human startle eyeblink electromyographic studies. Psychophysiology, 42(1), 1–15. 10.1111/j.1469-8986.2005.00271.x - DOI - PubMed
    1. Bottesi G, Gürdere C, Cerea S, Sica C, & Ghisi M (2020). Familial Patterns of Intolerance of Uncertainty: Preliminary Evidence in Female University Students. International Journal of Cognitive Therapy, 13(1), 30–41. 10.1007/s41811-019-00063-5 - DOI
    1. Bradley MM, Codispoti M, & Lang PJ (2006). A multi-process account of startle modulation during affective perception. Psychophysiology, 43(5), 486–497. 10.1111/j.1469-8986.2006.00412.x - DOI - PubMed

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