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Practice Guideline
. 2023 Jun;17(3):522-541.
doi: 10.1007/s12072-023-10510-3. Epub 2023 Apr 17.

Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver

Darrell H G Crawford  1   2 , Grant A Ramm  1   3 , Kim R Bridle  4   5 , Amanda J Nicoll  6   7 , Martin B Delatycki  8   9   10 , John K Olynyk  11   12
Affiliations
Practice Guideline

Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver

Darrell H G Crawford et al. Hepatol Int. 2023 Jun.
No abstract available

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Conflict of interest statement

Darrell Crawford, Grant Ramm, Kim Bridle, Amanda Nicoll, Martin Delatycki, and John Olynyk declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Intestinal Iron Absorption. Iron absorption occurs in the enterocytes of the small intestine before internalization of heme or non-heme iron. Ferrous iron is taken up by DMT1 following reduction by DCYTB. Excess iron is stored in ferritin or lost via enterocyte sloughing. Ferrous iron is exported via ferroportin, oxidized by hephaestin and transported by transferrin to various tissues for use or storage. Hepcidin senses body iron stores and acts as a negative regulator. Hepcidin binds to the iron export protein, ferroportin, on target cells and is responsible for the internalization and degradation of ferroportin. DMT1 divalent metal transporter 1, dcytb duodenal cytochrome B, RBC red blood cell, Fe3+ ferric iron, Fe2+ ferrous iron, Tf transferrin
Fig. 2
Fig. 2
Recommended Key Steps in the Clinical Evaluation of Hemochromatosis. Features which raise the need to suspect hemochromatosis are shown in Panel A (it is possible that more than one of these may be present at any one time), how to diagnose hemochromatosis in Panel B (the arrows represent the choice of options to consider), and how to assess for liver disease in Panel C. Panel D shows treatment, and Panel E shows follow-up (the arrows represent the range of issues to consider). APRI denotes aspartate aminotransferase-to-platelet ratio index, and FIB-4 Fibrosis-4 index. From The New England Journal of Medicine, John K. Olynyk and Grant A. Ramm, Hemochromatosis, Volume 387:2159–70. Copyright © (2022) Massachusetts Medical Society. Reprinted with permission, https://www.nejm.org/doi/full/10.1056/NEJMra2119758 [95]
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