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Review
. 2023 Jul;601(13):2593-2619.
doi: 10.1113/JP283792. Epub 2023 Apr 9.

Adapting to a new environment: postnatal maturation of the human cardiomyocyte

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Review

Adapting to a new environment: postnatal maturation of the human cardiomyocyte

Shatha Salameh et al. J Physiol. 2023 Jul.

Abstract

The postnatal mammalian heart undergoes remarkable developmental changes, which are stimulated by the transition from the intrauterine to extrauterine environment. With birth, increased oxygen levels promote metabolic, structural and biophysical maturation of cardiomyocytes, resulting in mature muscle with increased efficiency, contractility and electrical conduction. In this Topical Review article, we highlight key studies that inform our current understanding of human cardiomyocyte maturation. Collectively, these studies suggest that human atrial and ventricular myocytes evolve quickly within the first year but might not reach a fully mature adult phenotype until nearly the first decade of life. However, it is important to note that fetal, neonatal and paediatric cardiac physiology studies are hindered by a number of limitations, including the scarcity of human tissue, small sample size and a heavy reliance on diseased tissue samples, often without age-matched healthy controls. Future developmental studies are warranted to expand our understanding of normal cardiac physiology/pathophysiology and inform age-appropriate treatment strategies for cardiac disease.

Keywords: age dependence; cardiac electrophysiology; cardiomyocyte; development; excitation-contraction coupling; human physiology; maturation.

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Figures

Figure 1.
Figure 1.. Electron microscopy of fetal hearts
A, fetal hearts at 20 weeks of gestation, with some desmosomes forming at intercalated disc (arrows). Note scattered myofibrils. B, fetal heart at 30 weeks of gestation, with more abundant desmosomes at the intercalated disc and more densely packed myofibrils. Arrows indicate sarcoplasmic reticulum tubules at the Z-line, which were not present in the earlier period. Abbreviations: d, desmosomes; fa, fascia adherens; gj, gap junctions; mf, myofibrils. Scale bars: 0.53 μM. Adapted with permission from Kim et al. (1992).
Figure 2.
Figure 2.. Action potential morphology differs between neonatal and adult human atrial cardiomyocytes
Action potential waveforms recorded at stimulation cycle lengths (CL) of 1000 and 400 ms. Adapted with permission from Wang et al. (2003).

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References

    1. Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, … Mohamed TMA (2022). Transient cell cycle induction in cardiomyocytes to treat subacute ischemic heart failure. Circulation, 145(17), 1339–1355. - PMC - PubMed
    1. Adler C (1975). Relationship between deoxyribonucleic acid content and nucleoli in human heart muscle cells and estimation of cell number during cardiac growth and hyperfunction – PubMed. Recent Advances in Studies of Cardiac Structure and Metabolism, 8, 373–386. - PubMed
    1. Adler CP, & Costabel U (1975). Cell number in human heart in atrophy, hypertrophy, and under the influence of cytostatics. Recent Advances in Studies on Cardiac Structure and Metabolism, 6, 343–355. - PubMed
    1. Adler CP, & Costabel U (1980). Myocardial DNA and cell number under the influence of cytostatics – I. Post mortem investigations of human hearts. Virchows Archiv. B, Cell Pathology Including Molecular Pathology, 32(1), 109–125. - PubMed
    1. Adler CP, Friedburg H, Herget GW, Neuburger M, & Schwalb H (1996). Variability of cardiomyocyte DNA content, ploidy level and nuclear number in mammalian hearts. Virchows Archiv, 429, 159–164. - PubMed

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