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Review
. 2023 Jul;60(7):3963-3978.
doi: 10.1007/s12035-023-03320-z. Epub 2023 Apr 1.

Post-traumatic Stress Disorder: Focus on Neuroinflammation

Jimeng Li  1 , Lei Tong  2 , Bettina C Schock  3 , Li-Li Ji  4
Affiliations
Review

Post-traumatic Stress Disorder: Focus on Neuroinflammation

Jimeng Li et al. Mol Neurobiol. 2023 Jul.

Abstract

Post-traumatic stress disorder (PTSD), gaining increasing attention, is a multifaceted psychiatric disorder that occurs following a stressful or traumatic event or series of events. Recently, several studies showed a close relationship between PTSD and neuroinflammation. Neuroinflammation, a defense response of the nervous system, is associated with the activation of neuroimmune cells such as microglia and astrocytes and with changes in inflammatory markers. In this review, we first analyzed the relationship between neuroinflammation and PTSD: the effect of stress-derived activation of the hypothalamic-pituitary-adrenal (HPA) axis on the main immune cells in the brain and the effect of stimulated immune cells in the brain on the HPA axis. We then summarize the alteration of inflammatory markers in brain regions related to PTSD. Astrocytes are neural parenchymal cells that protect neurons by regulating the ionic microenvironment around neurons. Microglia are macrophages of the brain that coordinate the immunological response. Recent studies on these two cell types provided new insight into neuroinflammation in PTSD. These contribute to promoting comprehension of neuroinflammation, which plays a pivotal role in the pathogenesis of PTSD.

Keywords: Astrocyte; Inflammation; Microglia; Neuroinflammation; Post-traumatic stress disorder.

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References

    1. Koenen KC, Ratanatharathorn A, Ng L, McLaughlin KA, Bromet EJ, Stein DJ, Karam EG, Meron Ruscio A, Benjet C, Scott K, Atwoli L, Petukhova M, Lim CCW, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Bunting B, Ciutan M, de Girolamo G et al (2017) Posttraumatic stress disorder in the world mental health surveys. Psychol Med 47(13):2260–2274. https://doi.org/10.1017/S0033291717000708 - DOI - PubMed - PMC
    1. Watson P (2019) PTSD as a public mental health priority. Curr Psychiatry Rep 21(7):61. https://doi.org/10.1007/s11920-019-1032-1 - DOI - PubMed
    1. Koenen KC, Sumner JA, Gilsanz P, Glymour MM, Ratanatharathorn A, Rimm EB, Roberts AL, Winning A, Kubzansky LD (2017) Post-traumatic stress disorder and cardiometabolic disease: improving causal inference to inform practice. Psychological Medicine 47(2):209–225. https://doi.org/10.1017/s0033291716002294 - DOI - PubMed
    1. Roberts AL, Malspeis S, Kubzansky LD, Feldman CH, Chang SC, Koenen KC, Costenbader KH (2017) Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus in a longitudinal cohort of women. Arthritis Rheumatol 69(11):2162–2169. https://doi.org/10.1002/art.40222 - DOI - PubMed - PMC
    1. Ryder AL, Azcarate PM, Cohen BE (2018) PTSD and physical health. Current Psychiatry Reports 20(12):116. https://doi.org/10.1007/s11920-018-0977-9 - DOI - PubMed

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