Review

. 2023 Mar 21:15:411-425.

doi: 10.2147/IJWH.S397680. eCollection 2023.

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Ghayath Janoudi^{1

2}, Mara Uzun Rada³, Stephanie T Boyd¹, Deshayne B Fell^{2

4}, Joel G Ray⁵, Angel M Foster⁶, Randy Giffen⁷, Tammy J Clifford^{2

8}, Mark C Walker^{1

2

9

10

11

12}

Affiliations

¹ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
² School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
³ Independent Researcher, Ottawa, ON, Canada.
⁴ Children's Hospital of Eastern Ontario (CHEO) Research Institute, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁵ Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynecology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.
⁶ Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
⁷ IBM Canada, IBM, Toronto, ON, Canada.
⁸ Canadian Institute of Health Research, Government of Canada, Ottawa, ON, Canada.
⁹ International and Global Health Office, University of Ottawa, Ottawa, ON, Canada.
¹⁰ Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada.
¹¹ Department of Obstetrics, Gynecology & Newborn Care, The Ottawa Hospital, Ottawa, ON, Canada.
¹² BORN Ontario, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

PMID: 36974131
PMCID: PMC10039711
DOI: 10.2147/IJWH.S397680

Review

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Ghayath Janoudi et al. Int J Womens Health. 2023.

. 2023 Mar 21:15:411-425.

doi: 10.2147/IJWH.S397680. eCollection 2023.

Authors

Ghayath Janoudi^{1

2}, Mara Uzun Rada³, Stephanie T Boyd¹, Deshayne B Fell^{2

4}, Joel G Ray⁵, Angel M Foster⁶, Randy Giffen⁷, Tammy J Clifford^{2

8}, Mark C Walker^{1

2

9

10

11

12}

Affiliations

¹ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
² School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.
³ Independent Researcher, Ottawa, ON, Canada.
⁴ Children's Hospital of Eastern Ontario (CHEO) Research Institute, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
⁵ Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynecology, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.
⁶ Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada.
⁷ IBM Canada, IBM, Toronto, ON, Canada.
⁸ Canadian Institute of Health Research, Government of Canada, Ottawa, ON, Canada.
⁹ International and Global Health Office, University of Ottawa, Ottawa, ON, Canada.
¹⁰ Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON, Canada.
¹¹ Department of Obstetrics, Gynecology & Newborn Care, The Ottawa Hospital, Ottawa, ON, Canada.
¹² BORN Ontario, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.

PMID: 36974131
PMCID: PMC10039711
DOI: 10.2147/IJWH.S397680

Abstract

Background: Preeclampsia is a leading cause of maternal and perinatal mortality and morbidity. The management of preeclampsia has not changed much in more than two decades, and its aetiology is still not fully understood. Case reports and case series have traditionally been used to communicate new knowledge about existing conditions. Whether this is true for preeclampsia is not known.

Objective: To determine whether recent case reports or case series have generated new knowledge and clinical discoveries about preeclampsia.

Methods: A detailed search strategy was developed in consultation with a medical librarian. Two bibliographic databases were searched through Ovid: Embase and MEDLINE. We selected case reports or case series published between 2015 and 2020, comprising pregnant persons diagnosed with hypertensive disorders of pregnancy, including preeclampsia. Two reviewers independently screened all publications. One reviewer extracted data from included studies, while another conducted a quality check of extracted data. We developed a codebook to guide our data extraction and outcomes assessment. The quality of each report was determined based on Joanna Briggs Institute (JBI) critical appraisal checklist for case reports and case series.

Results: We included 104 case reports and three case series, together comprising 118 pregnancies. A severe presentation or complication of preeclampsia was reported in 81% of pregnancies, and 84% had a positive maternal outcome, free of death or persistent complications. Only 8% of the case reports were deemed to be of high quality, and 53.8% of moderate quality; none of the case series were of high quality. A total of 26 of the 107 publications (24.3%) included a novel clinical discovery as a central theme.

Conclusion: Over two-thirds of recent case reports and case series about preeclampsia do not appear to present new knowledge or discoveries about preeclampsia, and most are of low quality.

Keywords: HELLP syndrome; eclampsia; hypertensive disorders of pregnancy; study design.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

**Figure 1**
Flowchart of included and excluded studies.

See this image and copyright information in PMC

Cited by

The effectiveness of Allen Carr's method for smoking cessation: A systematic review.
Possenti I, Scala M, Lugo A, Clancy L, Keogan S, Gallus S. Possenti I, et al. Tob Prev Cessat. 2023 Sep 29;9:29. doi: 10.18332/tpc/172314. eCollection 2023. Tob Prev Cessat. 2023. PMID: 37780488 Free PMC article. Review.

References

1. McWhinney IR. Assessing clinical discoveries. Ann Fam Med. 2008;6(1):3–5. doi:10.1370/afm.801 - DOI - PMC - PubMed
1. Schulz KF, Grimes DA. The lancet handbook of essential concepts in clinical research. Lancet. 2006;2006:1.
1. Moyé LA. Statistical Reasoning in Medicine: The Intuitive p-value Primer. 2nd ed. New York, N.Y: Springer; 2006.
1. McWhinney I. Dr Olson’s discovery and the meaning of” scientific”. Can Fam Physician. 2004;50:1192. - PMC - PubMed
1. Newton I. The Principia: Mathematical Principles of Natural Philosophy. Univ of California Press; 1999.

Publication types

Actions

Grants and funding

We received no funding for this study.

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Affiliations

Do Case Reports and Case Series Generate Clinical Discoveries About Preeclampsia? A Systematic Review

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

Grants and funding

LinkOut - more resources

Full Text Sources

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

Related information

Grants and funding

LinkOut - more resources

Full Text Sources