Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul:52:86-93.
doi: 10.1016/j.carrev.2023.03.001. Epub 2023 Mar 7.

Cardiac MRI as an Imaging Tool in Titin Variant-Related Dilated Cardiomyopathy

Sandeep Banga  1 , Rhanderson Cardoso  2 , Carson Castellani  3 , Shaurya Srivastava  4 , Jennifer Watkins  5 , Joao Lima  2
Affiliations
Review

Cardiac MRI as an Imaging Tool in Titin Variant-Related Dilated Cardiomyopathy

Sandeep Banga et al. Cardiovasc Revasc Med. 2023 Jul.

Abstract

Dilated Cardiomyopathy is a common myocardial disease characterized by dilation and loss of function of one or both ventricles. A variety of etiologies have been implicated including genetic variation. Advancement in genetic sequencing, and diagnostic imaging allows for detection of genetic mutations in sarcomere protein titin (TTN) and high resolution assessment of cardiac function. This review article discusses the role of cardiac MRI in diagnosing dilated cardiomyopathy in patients with TTN variant related cardiomyopathy.

Keywords: Cardiac MRI; Dilated cardiomyopathy; Genetic; TITIN.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest None.

Similar articles

  • Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies.
    Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z; IMAC-2 and IPAC Investigators. Ware JS, et al. N Engl J Med. 2016 Jan 21;374(3):233-41. doi: 10.1056/NEJMoa1505517. Epub 2016 Jan 6. N Engl J Med. 2016. PMID: 26735901 Free PMC article.
  • Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation.
    Vikhorev PG, Vikhoreva NN, Yeung W, Li A, Lal S, Dos Remedios CG, Blair CA, Guglin M, Campbell KS, Yacoub MH, de Tombe P, Marston SB. Vikhorev PG, et al. Cardiovasc Res. 2022 Jan 7;118(1):241-253. doi: 10.1093/cvr/cvaa316. Cardiovasc Res. 2022. PMID: 33135063 Free PMC article.
  • Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy.
    Matsumoto Y, Hayashi T, Inagaki N, Takahashi M, Hiroi S, Nakamura T, Arimura T, Nakamura K, Ashizawa N, Yasunami M, Ohe T, Yano K, Kimura A. Matsumoto Y, et al. J Muscle Res Cell Motil. 2005;26(6-8):367-74. doi: 10.1007/s10974-005-9018-5. J Muscle Res Cell Motil. 2005. PMID: 16465475
  • Second Hits in Dilated Cardiomyopathy.
    Marstrand P, Picard K, Lakdawala NK. Marstrand P, et al. Curr Cardiol Rep. 2020 Jan 24;22(2):8. doi: 10.1007/s11886-020-1260-3. Curr Cardiol Rep. 2020. PMID: 31980956 Review.
  • Titin mutations and muscle disease.
    Kellermayer D, Smith JE 3rd, Granzier H. Kellermayer D, et al. Pflugers Arch. 2019 May;471(5):673-682. doi: 10.1007/s00424-019-02272-5. Epub 2019 Mar 27. Pflugers Arch. 2019. PMID: 30919088 Free PMC article. Review.
See all similar articles

LinkOut - more resources