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Review
. 2023 Jan 29;12(1):4.
doi: 10.1186/s13756-023-01210-6.

The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis

Amir Hossein Hasanpour  1 , Mahdi Sepidarkish  2 , Abolfazl Mollalo  3 , Ali Ardekani  4 , Mustafa Almukhtar  5 , Amal Mechaal  6 , Seyed Reza Hosseini  7 , Masoumeh Bayani  7 , Mostafa Javanian  8 , Ali Rostami  9
Affiliations
Review

The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis

Amir Hossein Hasanpour et al. Antimicrob Resist Infect Control. .

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs.

Objectives: We conducted a worldwide systematic review and meta-analysis on the prevalence and risk factors of MRSA in ECCs.

Methods: We searched MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases and the gray literature sources for all studies published between January 1980 and December 2022 on the prevalence of MRSA in ECCs. A random-effects model was utilized to estimate pooled prevalence rates at 95% confidence intervals (CI). Moreover, the data were analyzed based on World Health Organization-defined regions, income, and human development index levels.

Results: In total, 119 studies, including 164,717 participants from 29 countries, were found eligible for meta-analysis. The pooled global prevalence of MRSA was 14.69% (95% CI 12.39-17.15%; 16,793/164,717). Male gender [prevalence ratio (PR) = 1.55; 95% CI 1.47-1.64], previous MRSA infection (PR = 3.71; 95% CI 3.44-4.01), prior use of antibiotics (PR = 1.97; 95% CI 1.83-2.12), hospitalized within the previous year (PR = 1.32; 95% CI 1.20-1.45), have had any wound (PR = 2.38; 95% CI 2.23-2.55), have used urinary catheter (PR = 2.24; 95% CI 2.06-2.43), have used any medical device (PR = 1.78; 95% CI 1.66-1.91), and those with diabetes (PR = 1.55; CI 1.43-1.67) were more likely to be colonized by MRSA than other patients.

Conclusion: Screening programs and preventive measures should target MRSA in ECCs due to the high global prevalence rates.

Keywords: Long-term care; Methicillin-resistant Staphylococcus aureus; Nursing homes; Residential facilities; Systematic review.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The PRISMA diagram of the study selection
Fig. 2
Fig. 2
Worldwide distribution of MRSA colonization in ECCs
Fig. 3
Fig. 3
Meta-regression analyses of MRSA prevalence among elderly living in ECCs concerning A Country's gross national income per capita, B HDI level and C Publication year
See this image and copyright information in PMC

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