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. 2023 May 3;76(9):1567-1575.
doi: 10.1093/cid/ciac947.

Prevalence of Post-Coronavirus Disease Condition 12 Weeks After Omicron Infection Compared With Negative Controls and Association With Vaccination Status

Mayssam Nehme  1 , Pauline Vetter  2   3   4 , François Chappuis  5   6 , Laurent Kaiser  2   3   4 , Idris Guessous  1   6 ; CoviCare Study Team
Collaborators, Affiliations

Prevalence of Post-Coronavirus Disease Condition 12 Weeks After Omicron Infection Compared With Negative Controls and Association With Vaccination Status

Mayssam Nehme et al. Clin Infect Dis. .

Abstract

Background: Post-coronovirus disease (COVID) symptoms can persist several months after severe acute respiratory syndrome coronavirus 2 infection. Little is known, however, about the prevalence of post-COVID condition following infections from Omicron variants and how this varies according to vaccination status. This study evaluates the prevalence of symptoms and functional impairment 12 weeks after an infection by Omicron variants (BA.1 and BA.2) compared with negative controls tested during the same period.

Methods: Outpatient individuals who tested positive or negative for COVID-19 infection between December 2021 and February 2022 at the Geneva University Hospitals were followed 12 weeks after their test date.

Results: Overall, 11.7% of Omicron cases had symptoms 12 weeks after the infection compared with 10.4% of individuals who tested negative during the same period (P < .001), and symptoms were much less common in vaccinated versus nonvaccinated individuals with Omicron infection (9.7% vs 18.1%; P < .001). There were no significant differences in functional impairment at 12 weeks between Omicron cases and negative controls, even after adjusting for multiple potential confounders.

Conclusions: The differential prevalence of post-COVID symptoms and functional impairment attributed to Omicron BA.1 and BA.2 infection is low when compared with negative controls. Vaccination is associated with lower prevalence of post-COVID symptoms.

Keywords: Omicron; SARS-CoV-2; persistent symptoms; post-COVID; vaccination.

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Conflict of interest statement

Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. CoviCare Study Team . Mayssam Nehme, Pauline Vetter, Olivia Braillard, Frederic Assal, Frederic Lador, Ivan Guerreiro, Matteo Coen, Thomas Agoritsas, Jean-Luc Reny, Christophe Graf, Delphine S. Courvoisier, Lamyae Benzakour, Stéphane Genevay, Kim Lauper, Julien Salamun, Hervé Spechbach, Frederique Jacquerioz, Marwène Grira, Riccardo Favale, Guido Bondolfi, Aglaé Tardin, Paola M. Soccal, Dina Zekry, Silvia Stringhini, Philippe Meyer, Nana Kwabena Poku, Basile N. Landis, José Sandoval, Julien Ehrsam, Simon Regard, Camille Genecand, Garance Kopp, Gilles Allali, Samuel Cordey, Keith Harshman, Ioannis Xenarios, Lorenzo Cerutti, Cedric Howald, Henri Pegeot, Melyssa Elies, Deborah Penet, Pietro Cattaneo, Fosca Gattoni, Michael Bel, Damir Perisa, François Chappuis, Laurent Kaiser, Idris Guessous.

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