Associations of Dietary Intakes with Gynecological Cancers: Findings from a Cross-Sectional Study
- PMID: 36501056
- PMCID: PMC9739794
- DOI: 10.3390/nu14235026
Associations of Dietary Intakes with Gynecological Cancers: Findings from a Cross-Sectional Study
Abstract
Background: Gynecological cancers, including cervical cancer, ovarian cancer and endometrial cancer are leading causes of cancer-related death in women worldwide. Diet plays an important role in cancer development, which is widely accepted. However, the associations between dietary intakes and gynecological cancers remain unclear. Methods: A total of 12,437 women aged over 20 years from the National Health and Nutrition Examination Survey (NHANES), conducted from 2007−2016, were included in this study. The relationships between 30 dietary factors (4 macronutrients, 15 vitamins, 9 minerals, caffeine and alcohol) and gynecological cancers were assessed. Results: We observed negative correlations of intakes of phosphorus (odds ratio (OR), 95% confidence interval (CI); 0.998 (0.996, 0.999), p = 0.002) with cervical cancer, and intakes of vitamin B12 (0.812 (0.714, 0.925), p = 0.002), phosphorus (0.997 (0.996, 0.999), p < 0.001) and alcohol (0.971 (0.950, 0.992), p = 0.009) with endometrial cancer. The data showed positive associations of intake of caffeine (1.002 (1.001, 1.003), p = 0.003) with cervical cancer, and intake of copper (2.754 (1.313, 5.778), p = 0.009) with endometrial cancer. In addition, we found potential negative correlations between intake of vitamin B1 (p = 0.025) and cervical cancer; zinc (p = 0.048) and ovarian cancer; and potassium (p = 0.032) and endometrial cancer. Potential positive associations were found between intake of calcium and cervical cancer (p = 0.026) and endometrial cancer (p = 0.034), and between sodium (p = 0.042) and endometrial cancer. Intakes of protein, total sugars, total fat, cholesterol, vitamin A, alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, vitamin B2, niacin, vitamin B6, food folate, vitamin C, vitamin D, vitamin E, vitamin K, magnesium, iron and selenium showed no relationship with gynecological cancers (p > 0.05). Conclusions: Specific dietary factors were associated with gynecological cancers. More epidemiological studies are needed to validate our results.
Keywords: NHANES; cervical cancer; dietary factors; endometrial cancer; gynecological cancers; nutrients; ovarian cancer.
Conflict of interest statement
The authors declare no conflict of interest.
Similar articles
-
Vitamins in Gynecologic Malignancies.Nutrients. 2024 May 5;16(9):1392. doi: 10.3390/nu16091392. Nutrients. 2024. PMID: 38732639 Free PMC article. Review.
-
Nutritional intakes in community-dwelling older Japanese adults: high intakes of energy and protein based on high consumption of fish, vegetables and fruits provide sufficient micronutrients.J Nutr Sci Vitaminol (Tokyo). 2004 Jun;50(3):184-95. doi: 10.3177/jnsv.50.184. J Nutr Sci Vitaminol (Tokyo). 2004. PMID: 15386931
-
Associations of dietary B vitamins intakes with depression in adults.Int J Vitam Nutr Res. 2023 Apr;93(2):142-153. doi: 10.1024/0300-9831/a000720. Epub 2021 Jul 8. Int J Vitam Nutr Res. 2023. PMID: 34233510
-
Nutritional status of vitamin A, E, C, B1, B2, B6, nicotinic acid, B12, folate, and beta-carotene in young women.J Nutr Sci Vitaminol (Tokyo). 2001 Feb;47(1):20-7. doi: 10.3177/jnsv.47.20. J Nutr Sci Vitaminol (Tokyo). 2001. PMID: 11349886
-
Profile of gynecological cancers in a tertiary hospital, Eastern Nigeria.Pan Afr Med J. 2023 Mar 17;44:139. doi: 10.11604/pamj.2023.44.139.39034. eCollection 2023. Pan Afr Med J. 2023. PMID: 37333784 Free PMC article. Review.
Cited by
-
Review of the Potential Role of Ascorbate in the Prevention and Treatment of Gynecological Cancers.Antioxidants (Basel). 2024 May 19;13(5):617. doi: 10.3390/antiox13050617. Antioxidants (Basel). 2024. PMID: 38790722 Free PMC article. Review.
-
Vitamins in Gynecologic Malignancies.Nutrients. 2024 May 5;16(9):1392. doi: 10.3390/nu16091392. Nutrients. 2024. PMID: 38732639 Free PMC article. Review.
-
Epigallocatechin Gallate for the Treatment of Benign and Malignant Gynecological Diseases-Focus on Epigenetic Mechanisms.Nutrients. 2024 Feb 17;16(4):559. doi: 10.3390/nu16040559. Nutrients. 2024. PMID: 38398883 Free PMC article. Review.
-
Evaluation of the Main Macro-, Micro- and Trace Elements Found in Fallopia japonica Plants and Their Traceability in Its Honey: A Case Study from the Northwestern and Western Part of Romania.Plants (Basel). 2024 Jan 31;13(3):428. doi: 10.3390/plants13030428. Plants (Basel). 2024. PMID: 38337961 Free PMC article.
-
Relationship between human papillomavirus and serum vitamin D levels: a systematic review.BMC Infect Dis. 2024 Jan 13;24(1):80. doi: 10.1186/s12879-024-09006-8. BMC Infect Dis. 2024. PMID: 38216875 Free PMC article.
References
-
- Doubeni C.A., Doubeni A.R., Myers A.E. Diagnosis and Management of Ovarian Cancer. Am. Fam. Physician. 2016;93:937–944. - PubMed
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical